Sulfonylureas Flashcards
0
Q
How do sulfonylureas (glipizide) work?
A
They stimulate insulin release from pancreatic B cells
1
Q
Sulfonylureas have 2 generations. Why are first generations not used as much?
A
More AE. 2nd generations are 100x more potent (but not more effective)
2
Q
What are the 2 major AE of sulfonylureas?
A
Hypoglycemia and sulfa allergy
3
Q
What can contribute to hypoglycemia with sulfonylureas?
A
Skipped meals, exercise, alcohol use, longer acting sulfonylureas
4
Q
When should sulfonureas be taken? Why?
A
30 minutes before a meal for better absorption
