Lupus

Question 1

How does OCP use relate to SLE?

Answer 1

OCP can cause a flare of SLE

Question 2

What is the pathophysiology of Lupus?

Answer 2

Multisystem autoantibody attack and immune complex formation against products of apoptosis that are abnormally exposed to the immune system

Question 3

What Ix can be used to monitor the activity of lupus and complications?

Answer 3

Activity

• CRP, ESR
• FBE - Hb and WBCs
• Anti-ds-DNA antibody titres (ANA isn’t informative for activity)
• UEC, MSU (kidneys)
• Vitamin D
• LFT
• Complement C3 and C4 (not routine)

Question 4

What is the name of the rash commonly seen in lupus?

Answer 4

Malar rash

Question 5

What is SLE management medically?

Answer 5

Immunosuppresion:

• Hydroxychloroquine
• Steroids
• Biologics

Question 6

What are the antibodies specific to SLE that can be used from diagnosis?

Answer 6

Anti-RO

Anti-La

Anti-Smith

Question 7

What are the diagnostic criteria for lupus?

Answer 7

4+ of the following:

S - Serositis

O - Oral Ulcers

A - Arthritis/Athralgia

P - Photosensitivity

B - Blood disorder

R - Renal Impairment

A - ANA+

I - Anti-Smith, -Ro, -La

N - Neurological symptoms

M - Malar rash

D - Discoid rash

Question 8

What is the pattern of arthritis typically seen in SLE?

Answer 8

Symmetrical polyarthritis

Question 9

What are the most common presenting signs and symptoms of SLE?

Answer 9

Arthritis

Malar rash

Fever

Fatigue

Renal impairment/proteinuria

Mouth Ulcers

Seizures