TB

Question 1

What does RIPE stand for?

Answer 1

Rifampicin

Isoniazid

Pyrazinamide

Ethambutal

Question 2

What are the major side effects of each of the RIPE drugs?

Answer 2

Rifampicin - Elevated liver enzymes

• Pink stained body secretions

Isoniazide - Polyneuropathy due to B6 deficiency (prescribe pyridoxine to prevent this)

Pyrazinamide - Hepatic toxicity

• Gout

Ethambutol - optic retrobulbar neuritis

Question 3

When is greater than 6 months of treatment required?

Answer 3

CNS TB

Question 4

When is prednisolone used to supplement RIPE treatment?

Answer 4

When there is CNS and pericardial involvement

Question 5

What constitutes MDR TB?

Answer 5

TB that is resistant to rifampicin and ioniazid

Question 6

What are the CSF findings in CNS TB?

Answer 6

Protein >2-3g/L

Glucose <0.5 blood glucose

Question 7

What are some predisposing host factors for TB?

Answer 7

Immunosuppression

Chronic disease

IVDU, Alcohol

Malnutrition

Question 8

What is the classic appearance of a TB cavity?

Answer 8

Thin, regular wall

No air-fluid level