Parvoviridae

Question 1

Parvoviridae characteristics

Answer 1

nonenveloped, icosahedral, T=1

linear, single-stranded DNA, very stable

Question 2

Parvoviridae replication occurs in ___

Answer 2

the nucleus of dividing cells (during S phase), leads to large intranuclear inclusion bodies

Question 3

5 genera of parvovirinae

Answer 3

Parvovirus, Erythrovirus, Dependovirus, Bocavirus, Amdovirus

Question 4

Erythrovirus causes __

Answer 4

Slap cheek rash, fifth disease

Question 5

Slap cheek rash in humans is caused by parvovirus type ___

Answer 5

B19

No transmission btw humans and cats/dogs

Question 6

Slap cheek rash: Clinical signs

Answer 6

mild rash, aplastic anemia, painful joints

Question 7

Dependovirus must have a helper virus to replicate, this is usually ___

Answer 7

adenovirus

Question 8

Bocavirus contains an ___ btw non-structural and structural coding regions

Answer 8

3rd open reading frame

Question 9

Feline parvovirus is known as Feline ____

Answer 9

Feline panleukopenia (FPV)

Question 10

T or F

Nearly all cats are infected with FPV within the first year of life

Answer 10

True

Question 11

FPV: transmission

Answer 11

direct contact with secretions, feces, fomites
in-utero
mechanical transmission

Question 12

FPV replication first occurs in ___ (organ)

Answer 12

pharyngeal lymphoid tissue

Question 13

FPV: pathogenesis

Answer 13

destroys all WBC and lymphoid tissues
thrombocytopenia
enteritis

Question 14

FPV: In-utero clinical signs

Answer 14

Early- fetal reabsorption, abortion, mummies

Late- live kittens with neural damage, CNS, ocular damage, cerebellar hypoplasia, hydranecephaly

Question 15

FPV: clinical signs in adults

Answer 15

fever, depression, anorecia, rough coat, vomiting, diarrhea, severe dehydration, hypothermia, DIC, death

Question 16

T or F

you can vaccinate pregnant queens for FPV

Answer 16

False
May cause abortion, mummies, infertility
cerebellar hypoplasia and retinal damage in kittens

Question 17

FPV: diagnosis

Answer 17

clinical signs, necropsy, hematology, virus isolation, serology
fecal viral antigen using immunochromatography
PCR, direct hemagglutination

Question 18

FPV: treatment

Answer 18

supportive care, broad spectrum antibodies

Question 19

FPV: control

Answer 19

Vaccine

hygiene

Question 20

One of the most common infectious diseases of dogs is ____

Answer 20

Canine parvovirus-2

CPV-1 is mild illness and unimportant

Question 21

CPV-2: transmission

Answer 21

Oro-nasal exposure to feces
In-utero infection
fomites

Question 22

CPV-2: pathogenesis

Answer 22

Enteritis, Myocarditis, panleukopenia

Question 23

CPV-2: Diagnosis

Answer 23

CS, immunochromatography, ELISA, PCR, virus isolation

NOT serology because of vaccines or previous exposure

Question 24

CPV-2: Control

Answer 24

Vaccine

Hygiene

Question 25

CPV-2: Enteritis treatment

Answer 25

Oseltamivir (Tamiflu)

Question 26

Porcine parvovirus (PPV) infects the _____ system

Answer 26

Reproductive

Question 27

PPV: transmission

Answer 27

Oro-nasal followed by transplacental

Veneral

Question 28

T or F

If the sow is infected, all of her offspring will be infected at the same time

Answer 28

False

Each fetus has its own placenta, so infection happens are different rates

Question 29

Hallmark sign of PPV

Answer 29

Mummified fetuses

abortions are uncommon

Question 30

PPV is a major cause of ___

Answer 30

SMEDI

Stillbirth, mummification, embryo-death, infertility

Question 31

PPV: diagnosis

Answer 31

staining frozen fetal tissues

PCR, ELISA, HA, HI

Question 32

PPV: immunity

Answer 32

vaccinate all breeding stock

can cause persistent herd infection