4 Antipsychotics Flashcards Preview

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Flashcards in 4 Antipsychotics Deck (12):
1

Cautions with clozapine (3)

Agranulocytosis - check WBC counts. Patients should report symptoms of infection esp influenza like illness

Myocarditis and cardiomypathy - esp in first two months. (investigate before starting therapy. Monitor if tachycardic)

Intestinal obstruction - caution in patient taking constipating drugs. Recognize and treat constipation stat

2

Clozapine should be used in caution in patients taking drugs that cause................. such as...........

and drugs that might also cause

constipation
anti-muscurinics

agranularcytosis

3

How are the metabolic side-effects of anti psychotics measured?

monitor lipids and fasting blood glucose

4

Clozapine is typical or atypical

atypical (second gen)

5

If EPS side-effects are a particular concern use 1st or 2nd gen?

Second (atypical)

6

How long should an anti psychotic be tried for before it is deemed ineffective?

4-6 weeks

7

When is clozapine indicated?

two or more anti-psychotics have been tried (at least one of which was second gen)

8

main advantage of depot?

compliance

9

disadvantage of depot?

higher risk of EPS

10

Why do ECGs for antipsychotics

risk of prolonged QT interval

11

Caution when prescribing IM anitpsychotics for emergencies

The IM dose should be lower than oral (no first-pass effect), especially if pt is active (bloodflow to muscles increases absorbtion rate)

therefore Rx should not say route: PO/IM

12

What is neuroleptic malignant syndrome?

Rare and potentially fatal side-effect of antipsychotics
(hyperthermia, fluctuating consciousness, muscle rigidity, pallor, tachycardia, labile BP, urinary incontinence)