2015 Paper Flashcards Preview

1 Any - Pre-reg Exam > 2015 Paper > Flashcards

Flashcards in 2015 Paper Deck (54):
1

medication contraindicated in renal artery stenosis

ACEi
(they affect dilation of arteries...)

2

How might macrolides interact with some antipyschoyics?

Macrolides inhibit CYP

Clarithromycin not recommended with quetiapine

3

For significant results
p=

less than or equal to
0.05

4

If diuretics are given twice a day what times are appropriate?

No later than 4pm
so 8am and 2pm is suitable for BD

5

Pt counselling for mirtazepine

report signs of infection (fever, stomatitis, sore throat)
- risk of blood dyscrasia

6

Indication for mesna

Reduce haemorragic cycstitis (s/e of anticancer agents)

7

Medication causing haemorragic cycstitis?

Cyclophosphamaide

8

Which Vitamin aids the absorption of calcium

D

9

Can you crush finasteride?

Women of child baring potential should not handle crushed or broken tablets

10

Anti obesity drugs are indicated when....

BMI over 30
In whom at least 3 months of of managed care involving supervised diet, exercise and behaviour modification fails to achieve realistic reduction in weight
OR
BMI over 28 and other risk factors (T2DM, hypertension, hypercholesterolaemia)

11

Maximum treatment duration for orlistat

12 months

12

Risk of beta blockers in diabetes ?

Loss of warning of hypoglycaemia

13

Being dazzled by headlights is a side-effect of

Amiodarone

14

GI bleed causes stools to look....

Tarry in consistency

15

Causes of nausea due to medication etc that should be corrected and not treated with antiemetics

DKA
Digioxin and antiepileptic overdose

16

Main adverse effects of antihistamines

Antimuscurinic side effects and drowsiness

17

Mode of action of phenothiazine antiemetics (eg. ............)

Dopaminergic antagonists at chemoreceptors trigger zone

E.g. Prochloperazine and chlorpromazine

18

Problematic sideeffect of phenothiazines

Systemic reactions especially in children

19

Mode of action of metoclopramide

DA anatag acting on the GI

20

What antiemetic can be used in Parkinsons diease?

What is contraindicated ?

Dimperidone – it doesn't cross the BBB

NOT metoclopramide

21

Mode of action of domperidone

Da anatag - at the chemo trigger zone. Less

22

Metoclopramide use is cautioned due to .... Up to what age?

EPS
-19

23

Granisetron and ondansetron act on what? When are they used (2)

5HT Antagonist
Post op and cytotoxic

24

Dexamethasone is used to treat nausea due to

Chemotherapy

25

Aprepitant action ....
is used to treat....

Neurokinin receptor antagonist
Nausea due to cisplatins

26

What antiemetic can be used in pregnancy ?

None - but sometimes short term Promethazineo
Also supplementation with thiamine thiamine to prevent wernickes

27

Risk factors for post op nausea and vom

Female
Non smoker
History of post op or motion sickness
Opioids

28

Three drug classes in BNF recommended for post op nausea and vom

5HT antagonists (ondansetron)
Phenothiazines
Antihistamines

29

Most effective drug at preventing motion sickness

Hyoscine hydrobromide
Promethazine is useful for sedative effect
(Metoclopramide, domperidone, 5HT anatag and phenothiazines - except promethazine - are ineffective)

30

Uses of beta histine

Vertigo, tinnitus, hearing loss associated with Ménière's disease

31

Treatment for cradle cap

Olive or coconut oil or simple emollient

32

counselling for bisphosphonates 3

Report thigh, hip or groin pain.
Regular dental check ups.
Swallow whole with a full glass of water 30 mins before breakfast and other oral meds. Remain upright for 30mins.

33

How long until full effect of NSAIDs is achieved for
Pain
Inflammation

1 week for pain
3 weeks for inflammation

34

Less GI side effects when NSAIDs are selective for .....

Cox 2

35

Anti-inflammatory effects of ibuprofen are weaker therefore it is not suitable for...

Conditions where inflammation is prominent such as gout

36

First line NSAID is

Naproxen - lower incidence of side effects ( but more than ibuprofen)

37

Can methotrexate be given with ibuprofen ?

No- interaction with NSAIDS. Reduced excretion of methotrexate.

38

Can NSAIDs be given with Li

No. Interaction. Lithium excretion reduced by NSAIDs

39

Can NSAIDs be given with SSRIs?

No - increased bleeding risk

40

What anti diabetic drugs can't be used with NSAIDs

Sulfonyureas

41

Medications that interact with trimethoprim 3

Phenytoin
Methotrexate
Some antimalarials

42

Drug licensed for premature ejaculation and its mode of action

Dapoxetine - short acting SSRI.

43

Two drugs that are excreted unchanged into the bile and therefore can accumulate in hepatic impairment

Rifampicin
Fusidic acid

44

Hypo proteineamia in hepatic disease is associated with reduced protein binding which can cause toxicity with highly protein bound drugs such as (2)

Prednisolone and phenytoin

45

Medication that percipitate hepatic encephalopathy

Sedative drugs
Opioid analgesics
Diuretics that cause hyperkalaemia
Drugs that cause constipation X

46

Oedema and ascities in hepatic disease can be exacerbated by drugs that cause fluid retention such as 2

NSAIDs and corticosteroids

47

drug for urinary incontinance that is not antimuscurinic

merabegron

48

drugs that are contraindicated with imidazoles (miconazole) include

statins
Imidazoles inhibit CYP

49

can clobetasone butyrate or clobetasone propionate be bought over the counter?

clobetasone butyrate 0.05% (eumovate)

50

maximum OTC dose of hydrocortisone cream

1%

51

Guidance for OTC hydrocortisone preparations for haemorrhoids

Only for over 18s
Can be used in pregnancy and breastfeeding
No more than 7 days
Not for new suffers who should be referred

52

what is premarin for?
how long should premarin be left on for?
coucelling for this?

scabies
8-12 hours. If hands are washed in this time it should be reapplied

53

what is a once only application for athletes foot?
direction

Lamisil once (terbinifine 1%)
Wash off 24 hours after application

54

The initial and maximum dose of what statin depends on ethnicity

Rosuvastatin (start 5-10mg max 40mg)
Patients of asian origin (start at 5, max 20mg)