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Pharmacy Drugs COPY > 416 Exam 6 Cancer > Flashcards

416 Exam 6 Cancer Flashcards

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1
Q

Trt for neutropenia

A

Filgrastim 5mcg/kg
Pegfilgrastim 6mg
SE: Bone pain- premedicate w/APAP or Claritin

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2
Q

Neutropenic fever (pseudomonas) trt

A

Cefepime, Ceftazidime, Carbapenems, Zosyn
add Aminoglycoside or Cipro
add Vanco
Fungal: caspofungin

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3
Q

Trt for anemia

A 
Epoetin alpha (Epogen, Procrit) 
Darbepoetin (Aranesp)
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4
Q

Thrombocytopenia trt and prevention

A

Transfusion

Prevention: Oprelvekin 50mcg/kg (non-myeloid malignancy)

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5
Q

Mucositis trt and prevention

A

Trt: oral hygiene, pain relief (magic mouthwash, lidocaine)
Prevention: oral hygiene, chlorhexidine, Palifermin (severe mucositis)

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6
Q

Diarrhea trt

A

Hydration
Loperamide
Octreotide

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7
Q

Extravasation trt

A

Stop injection
Admin Totect for anthracyclines
Cold compresses

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8
Q

Peripheral neuropathy trt

A

Duloxetine

Gabapentin

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9
Q

Breast cancer- neoadjuvant therapy (pre/postmenopause, node+, >1cm)

A

Chemo + surgery + radiation (+/- Trastuzumab, Tamoxifen)

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10
Q

Breast cancer trt pre/postmenopause, ER/PR-

A

Surgery + chemo +/- Trastuzumab (NO endocrine)

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11
Q

Breast cancer trt premenopause, ER/PR+

A

Surgery + chemo + Tamoxifen 20mg + LHRH agonist (goserelin) +/- Trastuzumab

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12
Q

Breast cancer trt postmenopause, ER/PR+

A

Surgery + chemo + AI inhibitor (anastrozole 1mg/letrozole 2.4mg/exemetane 25mg) +/- Tamoxifen +/- Trastuzumab

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13
Q

Breast cancer stage IV trt premenopause ER/PR-

A

Chemo

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14
Q

Breast cancer stage IV trt premenopause ER/PR+

A

Tamoxifen +/- LHRH agonist (goserelin) +/- Trastuzumab

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15
Q

Breast cancer stage IV trt ER/PR+ postmenopause

A

AI inhibitor (anastrozole 1mg) +/- CDK inhibitor (Palbociclib) +/- Trastuzumab OR Lapatinib
OR
Fulvestrant +/- CDK inhibitor (Palbociclib) +/- Trastuzumab

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16
Q

Ovarian cancer trt

A

Surgery + chemo (paclitaxel + cisplatin)

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17
Q

Ovarian cancer trt Cisplatin resistant (recurrence <6months)

A

Chemo: docetaxel or gemcitabine or paclitaxel +/- pazopanib

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18
Q

Ovarian cancer trt when failed chemo >3 times BRCA-mutated

A

PARP inhibitor: Olaparib

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19
Q

Ovarian cancer trt when failed chemo >3 times (NOT BRCA specific)

A

PARP inhibitors: Niraparib, Rucaparib

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20
Q

Prostate cancer initial trt <10yrs life expectancy

A

Observation or radiation

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21
Q

Prostate cancer trt >10yr life expectancy AND localized disease

A

Prostatectomy

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22
Q

Prostate cancer initial trt >10yr life expectancy

A

Prostatectomy or Radiation +/- ADT (LHRH agonist: goserelin, leuprolide OR LHRH antagonist: degarelix)

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23
Q

Prostate cancer trt progressing castrate sensitive metastatic disease

A

ADT + bilateral orchidectomy OR LHRH agonist +/- antiandrogens (Flutamide, Nilutamide) OR LHRH agonist + docetaxel

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24
Q

Prostate cancer trt castrate resistant with PSA doubling time <10months

A

Androgen receptor inhibitor: Apalutamide

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25
Prostate cancer trt castrate resistant metastatic asymptomatic
Sipuleucel-T (vaccine)
26
Prostate cancer trt castrate resistant metastatic No visceral Mets
Enzalutamide OR Abiratenone +prednisone
27
Prostate cancer trt castrate resistant metastatic with visceral Mets
Docetaxel + prednisone (continue to progress: cabazitaxel)
28
Renal cell carcinoma trt stage I
Partial nephrectomy OR active surveillance
29
Renal cell carcinoma trt stage II
Radical nephrectomy
30
Renal cell carcinoma trt Stage III
Radical nephrectomy + VEGF inhibitor (Sunitinib)
31
Renal cell carcinoma trt Stage IV
Radical nephrectomy + IL-2 or Targeted therapy Options: Bevacizumab + IFN 2 mTOR inhibitor: Temsirolimus
32
SCLC limited stage trt
Radiation + chemo (cisplatin + etoposide)
33
SCLC extensive stage trt
Chemo (cisplatin or carboplatin + etoposide)
34
NSCLC stage I trt
Surgery + observation
35
NSCLC stage II trt
Surgery + chemo (cisplatin)
36
NSCLC stage III trt
Surgery + chemo (cisplatin) +/- radiation OR targeted therapy
37
NSCLC stage IV trt negative biomarker non-squamous
Chemo: PS 0-1: cisplatin/premetrexed +/- Bevacizumab PS 2: carboplatin/paclitaxel PS 3: best supportive care
38
NSCLC stage IV trt negative biomarker squamous
Chemo: PS 0-1: cisplatin/gemcitabine (NO Bevacizumab) PS 2: carboplatin/gemcitabine PS 3: best supportive care
39
NSCLC stage IV trt EGFR + biomarker
EGFR inhibitors: Gefitinib or Erlotinib | Osimertinib for T790M mutation
40
NSCLC stage IV trt EML4-ALK + biomarker
ALK inhibitors: Alectinib | Or Brigatinib, ceritinib, crizotinib
41
NSCLC stage IV trt ROS1+ biomarker
ALK inhibitors: Crizotinib | or Ceritinib
42
NSCLC stage IV trt PDL1+ biomarker
PDL1 inhibitors: Pembrolizumab | or Nivolumab, Atexolizumab
43
NSCLC stage IV trt BRAF+ biomarker
BRAF V600E inhibitors: Dabrafenib, Trametinib
44
Acute CINV
5HT3: Ondansetron 16-24mg PO, 8-16mg IV; Palonsetron 0.25mg IV; Dolansetron 100mg PO NK1: Aprepitant 125mg, 80mg, 80mg PO; Fosaprepitant 150mg IV; Rolapitant Steroids: Dexamethasone 12mg then 4-8mg x3days Olanzapine 10mg QD
45
Delayed CINV
5HT3: Palonsetron 0.25mg IV NK1: Aprepitant 125mg, 80mg, 80mg PO; Fosaprepitant 150mg IV; Rolapitant Steroids: Dexamethasone 12mg then 4-8mg x3days Olanzapine 10mg QD
46
Breakthrough CINV
DA: Prochlorperazine 12.5-25mg q4-6h; Promethazine 10mg q6h GABA: Lorazepam 1-2mg q4-6h Steroids: Dexamethasone 12mg then 4-8mg x3days Olanzapine 10mg QD 5HT3: Ondansetron 16-24mg PO, 8-16mg IV; Palonsetron 0.25mg IV; Dolansetron 100mg PO
47
Refractory CINV
``` Dronabinol ADH cocktail (Ativan, Diphenhydramine,Haloperidol) ```
48
HD stage I-IV favorable OR unfavorable nonbulky OR unfavorable bulky
ABVD +/- radiation | Doxorubicin, Bleomycin, Vinblastine, Dacarbazine
49
HD relapse <12months of ABVD
Stem cell transplant
50
HD fail stem cell transplant
Brentuximab + AVD
51
HD fail Brentuximab
PDL1: Nivolumab or Pembrolizumab
52
Non-HD indolent trt
Radiation +/- chemo
53
Non-HD aggressive trt (DLBCL)
Chemo + radiation | RCHOP: rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone
54
ALL remission induction trt
Vincristine + Dexamethasone + L-asparaginase | High risk: + daunorubicin
55
ALL CNS prophylaxis
Intrathecal cytarabine + hydrocortisone + MTX
56
ALL maintenance trt
Mercaptopurine + MTX + Dexamethasone + Vincristine | Ph+ add bcr-abl inhibitor
57
AML remission induction and consolidation trt
7 + 3 7 days of Cytarabine 3 days daunorubicin or idarubicin Consolidation= 7 + 3 higher doses
58
AML M3 induction trt
ATRA + idarubicin or arsenic trioxide
59
AML M3 consolidation trt
Arsenic + Cytarabine + Daunorubicin
60
AML M3 maintenance trt
ATRA +/- 6MP + MTX
61
CML chronic/accelerated trt
Bcr-abl inhibitors: Imatinib 400mg, Dasatinib 100mg, Nilotinib 300mg, Bosutinib 400mg t315i mutation: Panatinib
62
CLL trt
Watch and wait (asymptomatic) Ibrutinib FCR (young pts): Fludarabine, Cyclophosphamide, rituximab
63
Colon cancer stage I
Surgery (no chem, no adjuvant)
64
Colon cancer stage II
Surgery + chemo (ONLY if high risk)
65
Colon cancer stage III
Surgery + adjuvant chemo (FOLFOX: 5FU, oxaliplatin, leucovorin)
66
Colon cancer stage IV
Surgery + adjuvant chemo (FOLFOX +/- Bevacizumab) | 5FU, Oxaliplatin, Leucovorin
67
Melanoma trt
Surgery +/- adjuvant (Nivolumab) | No role for chemo
68
Melanoma metastatic BRAF-
Checkpoint inhibitors: Pembrolizumab, Nivolumab
69
Melanoma metastatic BRAF+
BRAF inhibitors: Dabrafenib + Trametinib
70
Melanoma metastatic CNS penetration
Temozolamide
71
Non-melanoma (basal or squamous cell) trt
Surgery +/- radiation +/- topical 5FU or Imiquimod | No role for chemo
72
Non-melanoma last line trt
Hedgehog: Vismodegib or Sonidegib

Pharmacy Drugs COPY (37 decks)

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