Antibiotics MOA Flashcards by Hope Manning

Q

Cycloserine

A

Cell Wall Synthesis

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Q

Vancomycin

A

Cell Wall Synthesis

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Q

Bacitracin

A

Cell Wall Synthesis

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Q

Fosfomycin

A

Cell Wall Synthesis

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Q

Penicillins

A

Cell Wall Synthesis

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Q

Cephalosporins

A

Cell Wall Synthesis

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Q

Monobactams

A

Cell Wall Synthesis

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Q

Carbapenems

A

Cell Wall Synthesis

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Q

Cell Wall Synthesis

A

Cycloserine
Vancomycin
Bacitracin
Fosfomycin
Penicillins
Cephalosporins
Monobactams
Carbapenems

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Q

Polymyxins

A

Cell Membrane

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Q

Cell Membrane

A

Polymyxins

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Q

Trimethoprim

A

Folic Acid Metabolism

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Q

Sulfonamides

A

Folic Acid Metabolism

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Q

Folic Acid Metabolism

A

Trimethoprim

Sulfonamides

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Q

Nalidixic Acid

A

DNA Replication (Gyrase)

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Q

Quinolones

A

DNA Replication (Gyrase)

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Q

DNA Replication (Gyrase)

A

Nalidixic Acid

Quinolones

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Q

Rifampin

A

DNA-dependent RNA Polymerase

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Q

DNA-dependent RNA Polymerase

A

Rifampin

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Q

Erythromycin

A

Protein Synthesis (50s Inhibitor)

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Q

Chloramphenicol

A

Protein Synthesis (50s Inhibitor)

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Q

Clindamycin

A

Protein Synthesis (50s Inhibitor)

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Q

Protein Synthesis (50s Inhibitor)

A

Erythromycin
Chloramphenicol
Clindamycin
Linezolid

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Q

Tetracycline

A

Protein Synthesis (30s Inhibitor)

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Spectinomycin

Protein Synthesis (30s Inhibitor)

Streptomycin

Protein Synthesis (30s Inhibitor)

Gentamicin/Tobramycin

Protein Synthesis (30s Inhibitor)

Amikacin

Protein Synthesis (30s Inhibitor)

Protein Synthesis (30s Inhibitor)

``` Tetracycline Spectinomycin Streptomycin Gentamicin/Tobramycin Tigecycline ```

All abx side effects

Allergy | C diff

Beta lactams side effect

Neutropenia Thrombocytopenia Seizures

Nafcillin side effect

Thrombophlebitis | Neutropenia

Ceftriaxone side effect

Biliary sludge formation

Macrolides side effect

GI upset Thrombophlebitis P450 inhibitor Bone marrow suppression

AGs side effect

Nephrotoxicity Ototoxicity Neuromuscular blockade

Vanco side effect

Nephrotoxicity Ototoxicity Neuromuscular blockade

FQN side effect

``` Phototoxicity CNS side effect QT prolongation Hypo/hyperglycemia Al/Ca/Mg ion interactions ```

Tetracycline side effect

N/V, diarrhea Phototoxicity CNS side effect Al/Ca/Mg ion interactions

Tigemycin side effect

N/V/diarrhea Phototoxicity CNS side effect Al/Ca/Mg ion interactions

Daptomycin side effect

Elevated CPK

Linezolid side effect

Thrombocytopenia Optic neuritis Serotonin syndrome

Clindamycin side effect

N/V/D

Metronidazole side effect

Metallic taste | P450 inhibitor

G+ resistance mechanism

Change PBPs Beta-lactamases Efflux pump

G- resistance mechanisms

Beta-lactamases Efflux pump Enzyme mediated degradation Change membrane permeability

Macrolide that is NOT P450 inhibitor

Azithromycin

Linezolid

Protein Synthesis (50s)

Metronidazole

DNA Synthesis

Broad spectrum PCNs

Amoxicillin | Ampicillin

Narrow Spectrum PCNs

PCN G | PCN V

Penicillinase-resistant PCNs (anti-staph PCNs)

Cloxacillin Naficillin Dicloxacillin Oxacillin

Extended-spectrum PCN (anti-pseudomonas PCNs)

Piperacillin | Ticacillin

Beta-lactamase inhibitors

Clavulanic acid Sulbactam Tazobactam

G+ activity Cephalosporins

First gen

First generation Cephalosporins

``` Cephalexin Cephalothin Cephradine Cefazolin Cefadroxil ```

G- activity Cephalosporins

2-4 gen increasing

Second gen Cephalosporins

``` Cefuroxime Cefamandole Cefaclor Cefaranide Cefoxitin Cefotitan ```

Third gen Cephalosporins

``` Cefotaxime Ceftriaxone Cefodizime* Ceftizoxime* Ceftazidime* Cefoperazone* *anti-pseudomonas activity ```

Fourth gen Cephalosporins

Cefepime

Broad spectrum beta-lactams last resort

Carbapenems: Ertepenam Imipenam Meropenam

Monobactams

Aztreonam

Broad spectrum abx

``` Carbapenams Chloramphenicol 2-4 gen cephalosporin FQ Broad spectrum PCNs Tetracycline Sulfonamides ```

Narrow spectrum abx

PCN G and V Clindamycin Vancomycin (only G+) Daptomycin

Carbapenem that doesn't cover pseudomonas

Ertapenam

Telavancin side effect

Teratogenic | QT elongation

DDI with ritonavir because it has ethanol in it (disulfiram)

Metronidazole