Tamsulosin / Flomax

Question 1

Cost

Answer 1

5-70 per month

Question 2

Drug Class

Answer 2

Pharmacologic Class: selective alpha 1 adrenoceptor blocker;
Therapeutic Class: treatment of obstructive symptoms of BPH

Question 3

Pharmacodynamics

Answer 3

Selectively blocks alpha1 receptors but preferentially in the prostate, leading to relaxation of SM in the bladder neck and prostate, improving urine flow and reducing obstructive symptoms of BPH venoconstriction

Question 4

Pharmacokinetics

Answer 4

Completely absorbed after oral ingestion; >90% metabolized by CYP 450 enzymes; half-life about 6 hours, but duration of action up to 15 hours due to slow absorption

Question 5

Toxicity

Answer 5

Excessive hypotension with syncope, especially orthostatic, especially in patients on diuretics, allergic reactions, decreased libidio

Question 6

Interactions

Answer 6

Additive effects with most other antihypertensives, especially diuretics

Question 7

Special Considerations

Answer 7

Rule out carcinoma of prostate before beginning treatment; do not crush or chew tablets, as that will speed up absorption; can also be used to treat spasm of ureter in patients with kidney stones

Question 8

Indications and Dose / Route

Answer 8

for symptoms of BPH, 0.4 mg po qd or bid; similar doses for renal colic

Question 9

Monitor

Answer 9

BP