Labetalol / Transdate Flashcards

1
Q

Alternate Names

A

Carvedilol / Coreg Cost 4 - 26$

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2
Q

Drug Class

A

Pharm: alpha and beta receptor blocker
Therapeutic: Antihypertensive, treatment of CHF (Coreg)

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3
Q

Pharmacodynamics

A

Reduces BP by blocking access of NE to beta receptors and alpha 1 receptors; thereby lowering BP by several different mechanisms; patients differ in degree of beta-blockade vs alpha blockade

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4
Q

Pharmacokinetics

A

Excellent absorption but high first pass effect, leading to F~25%; onset 1-2 hours after po, 2-5 minutes when given IV; extensively metabolized in liver by IID6

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5
Q

Toxicity

A

Avoid in patient with Bradycardia, heartblock, CHF, asthma, shock; use with caution in patients with cardiomyopathy, pheochromocytoma, Pregnancy Class B

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6
Q

Interactions

A

Additive effects with most other anti-hypertensives

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7
Q

Special Consideration

A

Use reduced doses in patients with imparied liver function; dizziness is most troubling early side effect; most often used for hypertensive crises (with Nitroprusside)

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8
Q

Indications and Dose / Route

A

Most commonly given IV, with initial small boluses of 20 mg, followed by continuous infusion at 2 mg / min; not usually given po for chronic treatment; 80 mg tid, or 240 SR once daily

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9
Q

Monitor

A

BP HR

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10
Q

Notes

A

Carvediol / Coreg - first beta blocker shown to improve survival with moderate to severe CHF -> reduce toxic remodeling in ventricular tissues
Also given to pregnant women during pregnancy
Also given to patients with pheochromocytoma?

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