Physostigmine (generic) Flashcards

1
Q

Description

A

Reversible cholinesterase inhibitor

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2
Q

Actions

A

Indirectly stimulates both nicotinic and muscarinic acetylcholine receptors

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3
Q

Indications

A

Glaucoma, Alzheimers disease, delayed gastric emptying, anticholinergic toxicity with CNS effects e.g. atropine overdose, nondepolarizing neuromuscular blockade reversal

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4
Q

Toxicity

A

Cholinergic reaction (DUMBBELSS)

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5
Q

Other Facts

A

Crosses the BBB so not used for myasthenia gravis (uncharged and lipid soluble), IV / IM

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