BLI 2 - Erythropoiesis & Diagnosis (Siddiqui) Flashcards

1
Q

RBC shape: Multiple, blunt, rounded projections [liver disease, abetalipoproteinemia]

A

Acanthocyte

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2
Q

RBC shape: Target cell [asplenia, HbC disease, liver disease]

A

Codocyte

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3
Q

RBC shape: Tear drop cell [myelofibrosis]

A

Dacrocyte

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4
Q

RBC shape: Bite cell [G6PD deficiency]

A

Degmacyte

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5
Q

RBC shape: Sickle cell [sickle cell anemia]

A

Drepanocyte

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6
Q

RBC shape: Short, evenly-spaced, sharp surface projections [kidney disease, EDTA artifact, pyruvate kinase deficiency]

A

Echinocyte

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7
Q

RBC shape: oval-shaped [iron deficiency]

A

Elliptocyte

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8
Q

RBC shape: Fragmented RBC, helmet cell [DIC, TTP/HUS]

A

Schistocyte

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9
Q

RBC shape: Dense cell lacking central pallor [autoimmune hemolytic anemia, hereditary spherocytosis]

A

Spherocyte

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10
Q

RBC shape: Fish mouth-shaped [hereditary stomatocytosis, artifact]

A

Stomatocyte

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11
Q

RBC inclusion: ribosomes & polyribosomes

A

Basophilic stippling

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12
Q

RBC inclusion: residual microtubules from mitotic spindle

A

Cabot rings

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13
Q

RBC inclusion: denatured, precipitated hemoglobin, requires supravital stain

A

Heinz bodies

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14
Q

RBC inclusion: result of oxidant hemolysis

A

Heinz bodies

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15
Q

RBC inclusion: rod-shaped, dense-staining

A

Hemoglobin C crystals

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16
Q

RBC inclusion: condensed non-functional nuclear material

A

Howell-Jolly bodies

17
Q

RBC inclusion: seen at post-splenectomy

A

Howell-Jolly bodies

18
Q

RBC inclusion: aggregates of iron, ribosomes, mitochondria

A

Pappenheimer bodies

19
Q

Associated with a grape-like cluster agglutination of RBCs

A

immune-mediated anemia

20
Q

Associated with rouleaux formation resembling a stack of coins

A

Multiple myeloma

21
Q

Indication for bone marrow biopsy

A

Aplastic anemia