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Block 6 Exam 1 > BLI 9 - Normocytric Anemia II (Siddiqui) > Flashcards

BLI 9 - Normocytric Anemia II (Siddiqui) Flashcards

1
Q

Usually asymptomatic but may have difficulty concentrating urine

A

Hb SA (sickle cell trait)

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2
Q

In sickle cell disease, hemolysis is mostly _______

A

extravascular

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3
Q

Sickle cell disease point mutation

A

Glutamic acid to valine at 6th position

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4
Q

RIsk due to autosplenectomy

A

risk of infection from encapsulated organisms Spleen has fibrosed due to ischemia and infarction –> autosplenectomy

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5
Q

Spherocytosis w/ positive coombs test

A

AIHA

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6
Q

O157:H7

A

HUS Verotoxin causes endothelial cell damage –> platelet microthrombi –> schistocytes

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7
Q

Organism responsible for osteomyelitis in the a patient with sickle cell disease

Organism responsible for osteomyelitis in normal pt

A

Salmonella typhi S. aureus

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8
Q

Clinical manifestations for TTP/HUS

A

FAT RN

Fever

Anemia

Thrombocytopenia

Renal insufficiency – more HUS

Neurologic abnormalities – more TTP

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9
Q

Homozygous Hb S

A

Sickle cell disease

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10
Q

vaso-occlusive crisis

A

Sickle cell disease – sickled RBCs obstruct microvasculature

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11
Q

Schistocytes

A

MAHA

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12
Q

Hb C disease mutation

A

Glutamic acid –> Lysine at 6th position

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13
Q

Pancytopenia

Low RI

Paroxysmal Nocturnal Hemolysis

A

Aplastic Anemia

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14
Q

Hb SS vaccine

A

Pneumococcal

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15
Q

Heterozygous Hb S

A

Sickle cell trait

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16
Q

S. pneumo H. flu

A

Encapsulated organisms with increased risk of infection after autosplenectomy

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17
Q

Aplastic crisis

Stroke

Acute chest syndrome

Autosplenectomy

Aseptic necrosis

Skin infections/ulcers

A

Sickle cell disease

18
Q

Detects antibody-coated RBCs

A

Direct Coombs test

19
Q

Target cells Hb crystals

A

Hb C disease

20
Q

Best screening test for DIC

A

D-dimer

21
Q

IgM mediated AIHA: hemolysis

A

Intravascular hemolysis

22
Q

Sepsis

Abruptio placentae

Trauma/burns

Acute promyelocytic leukemia

A

Etiologies of DIC

23
Q

Sickle cell disease effect on bone marrow

A

Necrosis

24
Q

Tx of TTP/HUS includes plasmaphoresis and steroids, but never ________

A

platelet transfusion

25
Q

Hematopoietic stem cell defect

A

Aplastic Anemia

26
Q

Like thalassemia, shows crewcut appearance on xray with chipmunk facies and hepatomegaly

A

Sickle cell disease

27
Q

SLE, RA CLL PCN, quinidine, methyldopa

A

Warm agglutinin AIHA diseases

28
Q

IgM (complement-fixation): Cold or warm Extravascular or intravascular

A

Cold Intravascular

29
Q

Pulmonary risk of sickle cell disease

A

Acute chest syndrome

30
Q

Initial presentation of sickle cell disease >6 mo

A

Dactylitits

31
Q

Stroke/TIA sequelae Hypersplenism

A

Chronic complications of sickle cell disease

32
Q

IgG mediated AIHA: hemolysis

A

Extravascular hemolysis

33
Q

Sickle cell disease confirmatory test

A

Hemoglobin electrophoresis

34
Q

Sickle cell disease inheritance pattern

A

Autosomal recessive

35
Q

3 deoxygenated states that cause Hb S polymerization

A

Hypoxemia Acidosis Dehydration

36
Q

Components of Microangioapthic Hemolytic Anemia (MAHA)

A

TTP/HUS & DIC

37
Q

Mycoplasma pneumoniae Infectious Mononucleosis

A

Cold agglutinin AIHA diseases

38
Q

ADAMTS13

A

TTP Decreased ADAMTS13 = failure to cleave large vWF multimers –> platelet microthrombi –> schistocytes

39
Q

IgG (Opsonization): Cold or warm Extravascular or intravascular

A

Warm Extravascular

40
Q

In sickle cell disease, this form of hemoglobin is protective against sickling

A

Hb F

41
Q

Detects antibodies in serum

A

Indirect Coombs test

42
Q

Hydroxyurea

A

Increased Hb F –> protective against sickling

Block 6 Exam 1 (8 decks)

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