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Block 6 Exam 1 > BLI 7 - Macrocytic Anemia (Siddiqui) > Flashcards

BLI 7 - Macrocytic Anemia (Siddiqui) Flashcards

1
Q

Salivary gland secretion

A

R-binder

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2
Q

Increased serum methylmalonic acid

A

Megaloblastic - B12 deficiency only!

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3
Q

Microcytic sideroblastic anemia

A

Alcohol can also produce this

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4
Q

alcohol liver disease hypothyroidism MDS reticulocytosis

A

non-megaloblastic

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5
Q

Jejunum

A

folic acid absorption

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6
Q

Cofactor for conversion of homocysteine to methionine

A

Vit B12

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7
Q

Inhibits dihydrofolate reductase

A

MTX

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8
Q

Terminal ileum

A

B12 absorption

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9
Q

Years to develop

A

B12 deficiency

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10
Q

Alcoholics Pregnancy Hemolysis

A

Folate deficiency

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11
Q

Autoimmune destruction of gastric parietal cells

A

Pernicious anemia –> no intrinsic factor

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12
Q

Dissociates cobalamin (B12) from R-binder

A

Pancreatic enzymes

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13
Q

Gastric parietal cell secretions

A

R-binder Intrinsic Factor

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14
Q

Leafy green vegetables

A

Folic acid

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15
Q

N10 Formyl THF

A

Purine synthesis

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16
Q

Months to develop

A

Folate deficiency

17
Q

Impaired DNA synthesis

A

Megaloblastic anemia

18
Q

Gastrectomy Ileal resection Pancreatic insufficiency Crohn disease Diphyllobothrium latum Vegans (Not vegetarians)

A

B12 deficiency

19
Q

Animal derived foods

A

B12

20
Q

Cytoplasmic dyssynchrony - maturation of nucleus of bone marrow precursor cells is delayed relative to maturation in cytoplasm

A

megaloblastic

21
Q

hypersegmented neutrophils

A

megaloblastic

22
Q

Round macrocytes

A

Non-megaloblastic

23
Q

Enzyme to convert folic acid to THF

A

Dihydrofolate reductase

24
Q

Absent neutrophil hypersegmentation

A

Non-megaloblastic

25
Q

Increased serum homocysteine

A

Megaloblastic - B12 or Folate deficiency

26
Q

The Cbl-____ complex is taken up by endocytosis, the Cbl is liberated, and converted to two coenzyme forms (___-Cbl, adenosyl-Cbl)

A

TCII methyl

27
Q

N5 methyl THF

A

Methionine synthesis

28
Q

Pernicious anemia

A

B12 deficiency

29
Q

Most common cause of macrocytosis

A

Alcoholism

30
Q

MCV 100-110

A

Non-megaloblastic anemia

31
Q

Cofactor for methylmalonyl CoA to Succinyl CoA

A

Vit B12

32
Q

Negative lab important for dx of folate deficiency

A

NL methylmalonic acid level

33
Q

Parasthesias Weakness Visual impairment

A

Megaloblastic

34
Q

Drugs associated with megaloblastic anemia

A

MTX Sulfa Trimethoprim Phenytoin

35
Q

Increased lab values (2) in B12 deficiency

A

Homocysteine Methylmalonic Acid

36
Q

MCV > 110

A

megaloblastic anemia

37
Q

______ folate is more reliable, as it remains stable over time

A

RBC (more reliable than serum)

38
Q

N5,N10 methylene THF

A

Thymidine synthesis

Block 6 Exam 1 (8 decks)

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