Bipolar Flashcards
Affects synthesis, storage, release, reuptake of NE, serotonin, dopa, ach, gaba
Lithium
Competes w Ca, Mg, K, Na, in body tissue and sites
Lithium
Not metabolized, it’s renally excreted (renal dysfunction can double half life)
Lithium
Treats mania and depression
Decrease # of acute manic episodes
Lithium
Use for - schizophrenia, migraine, impulse control, aggression
Lithium
AD- GI problems, nausea, polydipsia, polyuria, nocturia, dry mouth, hand tremor, leukocytosis, m weakness, difficulty concentrating, impaired memory
Lithium
Long term effect of lithium
Weight gain, rash n acne, hypothyroidism, psorias, alopecia, T wave changes, nephrotoxicity, diabetes insipidus, hand tremor
Overdose- >1.5 mEg/L
Agitation, confusion, headache, nystagmus, tremors
OD: >3
Need for dialysis
Twitching, seizure, irreversible brain damages, respiratory complications, coma, death
70-80% efficacy
Better long term treatment than other drugs (better absorbed)
Not affected by food
Lithium
Cons
Onset is 5-7d (antimanic in 10-21 d, antidepressant in 28 d)
Lithium
Decrease the dose in elderly Pts on diuretics, Pt w renal ds, Dehydrated pt, Pt w poor CO
Lithium monitoring
Lithium monitoring
Decrease the dose in elderly Pts on diuretics, Pt w renal ds, Dehydrated pt, Pt w poor CO
ECG - every 6-12 m (pt>50 yrs)
Lithium monitoring
Lithium monitoring
Get vitals, CBC, weight, thyroid functions, renal functions, urinalysis
