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Pharm > Alzheimer--------------------------------------------------EXAM2 > Flashcards

Alzheimer--------------------------------------------------EXAM2 Flashcards

1
Q

Rivastigmine (Exelon)

A

Carbamate, AchE inhi

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2
Q

Inc *10 affinity for brain

A

Rivastigmine (Exelon)

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3
Q

Use for mild to moderate Alzheimer

A

Rivastigmine (Exelon)
Galantamine
Tacrine
Donepezil

(Except Mementine)

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4
Q

AD

Headache, NVD

A

Rivastigmine (Exelon)

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5
Q

Long DOA

Available in patch for pt who doesnt remember to take it

A

Rivastigmine (Exelon)

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6
Q

NMDA ant

A

Memantine

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7
Q

Treat severe Alzheimer

A

Memantine

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8
Q

AD

Constipation, hypertension, cough, somnolence, headache, fatigue,

A

Memantine

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9
Q

Used alone or w an AchE inh

Comes in patch form

A

Memantine

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10
Q

AchE inh

A

Rivastigmine
Galantamine
Tacrine
Donepezil

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11
Q

Reversible, competitive,

Selective for brain AchE

Carbamate compound

A

Galantamine

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12
Q

Uses

Treat mild to moderate alzheimer

A

Galantamine

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13
Q

AD

GI prob, agitation, insomnia

A

Galantamine

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14
Q

AchE inh

Butyrylcholinesterase inh

A

Tacrine- cognex

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15
Q

Uses

Treats mild to moderate alzheimer (inc memory and cognition)

A

Tacrine

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16
Q

Int

Cimetidine (decrease clearance by 30%)

A

Tacrine

17
Q

AD:

Hepatotoxicity- occurs in 1st 8wks in 30% of pts

NVD

Agitation, anorexia

A

Tacrine

18
Q

Must be given every 6 h on an empty stomach

Increase dose over 12 wks to decrease AD

A

Tacrine

19
Q

AchE inh

Reversible, noncompetitive

Patch

A

Donepezil

20
Q

Uses

1st line of defense for Alzheimer, treats mild to moderate alzheimer

A

Donepezil

21
Q

No liver toxicity, given once daily(why it’s chosen over Tacrine)

A

Donepezil

22
Q

Has low peripheral activity (high selectivity for CNS AchE)

2 yrs later -> doesnt have effect

A

Donepezil

23
Q

Other treatment

A

Estrogen repel treat- possibly neuroprotective

Ginko-> not really used (INT: anti-platelet drug)

Antidepressants, antipsychotics-> to help mood, behavior disturbances

24
Q

Alzheimer’s ds

RiD MEGA Tackle

A 
Rivastigmine
Donepezil, Aricept
Memantine
Galantamine
Tacrine, cognex

Pharm (19 decks)

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