B + a1 Blockers/a1 blocker/a2 blocker----EXAM2

Question 1

3 rd gen nonselective
Dec cont and HR
Vasodilate (a1)

Answer 1

Carvedilol,

Labetalol

Question 2

4th gen, b1 selective

Answer 2

Nebivolol

Question 3

IND

Hypertension, compensated heard failure

Answer 3

Carvedilol

Question 4

Int (carvedilol)

Ride blood in ca ci

Answer 4

Rifampin
Digoxin
Blood pressure meds
Ca ch blockers
Cimetidine (inhi elimination)

Question 5

INT

Rifampin
Digoxin
Blood pressure meds
Ca ch blockers
Cimetidine (inhi elimination)

Answer 5

Carvedilol

Question 6

AD

Sexual dysfunction, depression, dyslipidemia, sleep disturb, bradycardia, hypotension, dizziness, fatigue

Answer 6

Carvedilol

Labetalol

Question 7

IND (Labetalol)

Answer 7

Hypertension(oral), hypertensive emergemcies (IV),

Hypertension due to pheochromocytoma

Acute aortic disection

Question 8

IND

Hypertension(oral), hypertensive emergemcies (IV),

Hypertension due to pheochromocytoma

Acute aortic disection

Answer 8

Labetalol

Question 9

INt (labetalol)

Answer 9

BP meds, cimetidine(inhi elimination)

Question 10

IV labetalol

Answer 10

More b blocking activity than a blocking activity(7:1)

Oral-> 3:1=b:a

Question 11

B + a1 blockers

Car lab navi

Answer 11

Carvedilol
Labetalol
Nebivolol

Question 12

a 1 blocker

Answer 12

Vasodilate- inhi catecholamine (lower BP)

Dec afterload of heart,
Dec peripheral vascular resistance

Question 13

a1 blocker

Aldo 에서 Tam나는 The Prada 신발 만듬

Answer 13

Alfuzosin- prostate selective for BPH

Doxazosin

Tamsulosin- prostate sele for BPH

Terazosin
Prazosin

Question 14

IND

a1 blocker

Answer 14

Hypertension,
Peripheral vascular ds (claudication)

Used in heart failure secondary to development of tachyphylaxis (not primary)

Benign prostate hypertrophy- only for tamsulosin and alfuzosin

Question 15

INT

a1 blocker

Answer 15

Verapamil, BP meds, NSAID

Verapamil- inc prazosin drug level

Question 16

AD

a1 blocker

Answer 16

Orthostatic hypotension- only after first dose(first dose effect)
-> inc risk in pt w sodium and water depletion

Dizzi, lightheadness, headache, drowsiness

Question 17

a1 blocker

Answer 17

Most pt require additional diuretic to help blunt sodium and water resorption

No deterious effect on lipid profiles

Question 18

a 2 blockers

GQ MC

Answer 18

Guanabenz
Quanfacine
Methyldopa- tears hypertensive emergencies in preg
Clonidine- (ad) sedation, drowsiness

Question 19

MOA

a 2 blockers

Answer 19

Blocks presynaptic a2 receptors located in CNS -> dec symp

Lower BP and HR- not 1st line drugs for HR though

Question 20

IND

a 2 blockers

Answer 20

Hypertension,
Heroin, alcohol, smoking withdrawal
Hypertensive emergencies
Menopausal hot flashes

Question 21

INT

a 2 blockers

Answer 21

TCA

B blockers: inc rebound effect when stopping therapy -> worsen clonidine withdrawal

Question 22

AD

a 2 blockers

Answer 22

Sedation
Dry mouth, depression
Drowsiness, dizzness->!side effects only for methyldopa: drug induced fever and lupus

Question 23

Abrupt d/c leads to severe rebound hypertension -> worsened by b-blockers

Titrate doses slowly- limit sedation

Answer 23

a 2 blockers