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Pharm > Anti Platelet----EXAM2 > Flashcards

Anti Platelet----EXAM2 Flashcards

1
Q

Irreversible inh of platelet cyclooxygenase

Long DOA: 6-10 days

A

Aspirin

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2
Q

Revesible inh of platelet cyclooxygenase inh

Short DOA

A

NSAID

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3
Q

IND

cyclooxygenase inh

A

Inhib clot formation in coronary or cerebral arteries

Anti-inflam

Anti-pyretic

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4
Q

Contra IND

Cyclooxygenase inh

A

Active GI ulcer, bleeding disorder,

Children

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5
Q

INT

Cyclooxygenase inh

A

Warfarin
Methotrexate
Valproic acid

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6
Q

AD

Cyclooxygenase inh

A

GI bleeding
Upset stomach
Tinnitus w high levels
Also nausea, vomiting, heart burn

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7
Q

Decrease risk of MI

A

Aspirin

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8
Q

Can cause gastric ulcers if large dose for long period -> can be prevented by enteric coating

A

Aspirin, NSAID

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9
Q

MOA

Selective ADP inh

A

Inh ADP receptors on the surface of platelets

  • prevent expression of GP IIb/IIIa receptors
  • prevent ADP-induced platelet aggregation
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10
Q

Selective ADP inh

A

Thiebopyridine class - irreversible ADP inh

Non- thienopyridine - reversible ADP inh

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11
Q

Thiebopyridine class - irreversible ADP inh

A

Ticlopidine
Clopidogrel
Prasugrel

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12
Q

AD

Ticlopidine

A

Neutropenia, thrombocytopenia, rash

Diarrhea

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13
Q

AD

Clopidorel -proton pump inh

A

Rash, diarrhea, bleeding

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14
Q

INT

Clopidogrel

A

Aspirin, warfarin, NSAID

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15
Q

IND

Prasugrel- potent, quick onset

A

Dec MI

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16
Q

AD

Prasugrel

A

High incidence of bleeding

17
Q

IND

Ticagrelor

A

Prevents mortality in MI

Reversible, so give it multiple times a day

18
Q

AD

Ticagrel

A

Short of breath
Dyspnea
Bentricular pause

19
Q

Cyclooxygenase inh

A

Aspirin, NSAID

20
Q

Angiotensin Ii

A

Vasoconstircts,

Inc aldosterone synthesis

21
Q

ACEI (angiotensin converting enzyme inhibitor)

A

All are prodrug except captopril, lisinopril, enalaprilat

Moexipril- prodrug

22
Q

MOA

ACEI (angiotensin converting enzyme inhibitor)

A

Inhibit conversion of angiotensin I to angiotensin II (blocks vasoconstiction)

Inhibit degradation of bradykinin

23
Q

IND

ACEI (angiotensin converting enzyme inhibitor)

A 
Hypertension
L ventr heart failure
Post MI
Hypertensive crisis
Captopril test
Raynaud's ds
24
Q

Contra IND

ACEI (angiotensin converting enzyme inhibitor)

A

Pregnancy(2nd, 3rd trimester)

Renal a stenosis

25
Q

INT

ACEI (angiotensin converting enzyme inhibitor)

A

NSAID, BP med,

Potassium supplement

26
Q

AD

ACEI (angiotensin converting enzyme inhibitor)

A

Abnormal taste, hypotension, cough
Hyperkalemia, renal problem, angioedema, dizziness, rash, drug fever
Neutropenia, agranulocytosis

Pharm (19 decks)

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