4.4 Neuroscience of Bipolar Disorder

Question 1

Waar gaat artikel van Han over?

Han et al. (2019)

Answer 1

Neuroimaging findings between bipolar depression and unipolar depression
- fMRI
- MRI

Question 2

What are the functional characteristics in bipolar depression?

Han et al. (2019)

In de PFC

Answer 2

1. Abnormally reduced VLPFC during emotion processing
2. Increased: stratium and medial PFC activity.
3. Reduced connectivity between OFC and amygdala during positive emotional stimuli
4. Increased OFC, VLPFC and stratium during reward activity

Question 3

What are functional characteristic in Bipolar Depression?

In emotion plekken brein

Answer 3

1. Dysfunction limbic circuit (emotion regulation)
2. Hypersensitivity fronto-stratial circuit (reward processing)
3. Increased: amygdala activity.

Question 4

Structural characteristics of BD

Han et al. (2019)

Answer 4

1. Reduced gray matter volume and thickness in: PFC, insula and temporal regions.
2. Reduced amygdala and hippocampal volume and reduced white matter in frontal regions.

Question 5

Conclusion

BD vs. UD in amygdala:

Han et al. (2019)

Answer 5

BD associated with greater activation in amygdala towards positive stimuli

UD associated with greater activation amugdala towards nega stimuli

Question 6

BD vs. UD in fronto-striatal activity

Han et al. (2019)

Answer 6

Functional differences in fronto-striatal activity or deactivation of the DM network in BD vs. UD

Question 7

BD vs. UD in grey and white matter

Han et al. (2019)

Answer 7

BD, decrease gray matter volume in:
- Hippocampus
- Amygdala

UD, decrease gray matter volume in:
- ACC

BD, decrease in white matter intergrity in:
- Anterior corpus callosum
- Posterior cingulum