Block 3 - Hemoglobin Variants / Thalassemias

Question 1

defective beta globin synthesis leads to ineffective blank which causes an expansion of bone marrow for compensation which leads to blank bones which leads to severe blank in the dentary

Answer 1

erythropoiesis, irregular formed bones, malocclusion

Question 2

most at risk population for beta globin synthesis defects

Answer 2

mediterranean/middle east

Question 3

disease similar to thalassemia that is treated by blood transfusion but is not usually as severe as thalassemia and is in utero

Answer 3

Hb H

Question 4

blank can also be used to explain evolution in vertebrates

Answer 4

beta globin

Question 5

a stretch of dna that clearly resembles a known, functioning gene is called a blank if the gene is found in most or all individuals of the species but is not expressed normally

Answer 5

pseudogene

Question 6

many hemoglobin blank thalassemias have been defined as causes

Answer 6

beta