Flashcards in 45: Bone Tumors - Carnevale Deck (35)
what are the 5 questions to ask?
1. what is the lesion's pattern of growth?
2. are the cells of the lesion producing anything?
3. what do the cells of the lesion look like?
4. based on cellular features and imaging studies, is the lesion more likely benign or malignant?
5. does the anatomical diagnosis correlate with the clinical picture and the radiographic appearance of the lesion? -- if it doesn't carefully reconsider all of the information for the case!
what two sites can ALL of the lesions appear in?
around the knee and at the humerus
diaphysis tumor ***
ewing sarcoma *** always in the diaphysis
chondrosarcoma and osteosarcoma
giant cell tumor
- benign tumor mature bone
- 40-50 yo
- cortical bones of SKULL and FACE
- well-delimited odule
- prognosis: good, slow-growing, not invasive, no malignant
bone forming tumors
- osteoid osteoma and osteoblastoma
- benign neoplasms with identical histology
- differ in size, origin, x-ray and symptoms
x:ray - central area of tumor (nidus) usually radiolucent, surrounded by rim of sclerotic bone
bone tumor (osteoid osteoma/osteoblastoma)
painful bone tumor relieved by aspirin ***
- if not relieved by aspirin = osteoblastoma
- vertebral column
- less than 2 cm
malignant tumor producing osteoid***
most common primary malignant tumor of bone
metaphysis of long bones
- under 20
- small peak in elderly with predisposing conditons (secondary osteosarcoma)
- 20% with pulmonary mets at time of diagnosis
elevation of periosteum to produce an angle b/w surface of involved bone - osteosarcoma
what is key for osteosarcoma diagnosis?
- young 10-30 male 3x female
- metaphysis near epiphyseal plate
- polypoid growth/ mushroom shaped
- benign tumors of hyaline cartilage
- in medullary cavity = enchondroma
- metaphyses, hands and feet
- young 20-40
- small bones of hand and feet
chondrosarcoma is a tumor of the _______ skeleton
- 40-60 (rare in children)
- pelvic bones, axial skeleton **
small round blue tumors
ewing sarcoma is always from the ...
ewing sarcoma EWS vs. primitive neuroectrodermal tumor PNET
- uniform, undifferentiated small round blue cells
- cells form prominent Homer Wright rosettes with central fibrillary cores
when does a person get a fibrous cortical defect?
1st two decades of life
- young 10-30
- radiolucent, in diaphysis
immature woven bone surrounded by fibroblastic proliferation
giant cell tumor of bone aka
- giant cell tymor of bone
- 20-55 yo (mature skeleton)