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Micro > L8 > Flashcards

L8 Flashcards

1
Q

ETEC

A

Entertoxigenic E. coli

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2
Q

Vibrio causing diarrhea

A

Cholerae

Parahaemolyticus

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3
Q

Two main cholera types

A

El Tor

Classical

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4
Q

Cholerae virulence factors

A

Flagella
Pili to adhere to mucosa
Cholera toxin

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5
Q

How is cholera toxin encoded

A

Phage encoded

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6
Q

Vibrio diarrhea mechanism

A

CTX causes transfer of ADP from NAD–>activate Gs

AC stays active–> increase cAMP–>prevents Na reabsorption–> water is drawn into the lumen of intestine

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7
Q

ETEC
Responsible for
Toxins

A

30-45% of travelers diarrhea
Colonization factor antigens (cfa)
Heat labile toxin (LT)
Heat stable toxin (ST)

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8
Q

ETEC diarrhea mechanism

Enterotoxigenic

A 
LT activates AC
ST activates Gc
increase cAMP, cGMP
prevent na absorption
water drawn into lumen
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9
Q

Hybrids

A

EPEC

EHEC

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10
Q

Secretory diarrhea e coli

A

ETEC

EPEC

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11
Q

Dysentery e coli

A

EHEC

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12
Q

Urinary tract e coli

A

UPEC

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13
Q 
EPEC 
Prevalence in
symptoms
area of body
infectious dose
A 
Enteropathogenic
newborns
secretory diarrhea
distal small intestin
Large dose
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14
Q

Intimate adherence

A

Characteristic adherence pattern attach and effacing lesion
EPEC
EHEC

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15
Q

Intimate adherence steps

A

1 Bundle forming pili adhere
2 Syringe like secretion injects Tir into host
3 Tir binds to intimin on ecoli–pedestral formation

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16
Q

EPEC cause of diarrhea

A

No toxin
Malabsorption from microvili disruptions
Disrupt epithelial tight junctions

17
Q

EHEC enterohemorrhagic
Reservoir
What does it cause
Toxin

A 
Cattle reservoir
attaching effacing lesion
shiga like toxin
Hemorrhagic colits
hemolytic eremic syndrom
18
Q

EHEC action

A

Shiga like toxin attack blood vessels of large intestine

Intensified with inflammatory cytokines

19
Q

How to detect EHEC

A

cannot ferment sorbitol..everything else will be pink

20
Q

UPEC Uropathogenic

A

Acute cystitis

pyelonephritis

21
Q

Proteus mirabilis causes

A

uncomplicated UTI

More sever than ecoli

22
Q

Proteus mirabilis virulence factors

A 
Flagella
Urease: raises urin pH
-bacteria grow better
-teoxic to renal cellls
-increase stones
23
Q

Diagnose UTI

Proteus diagnosed by

A

> 100,000 CFU/ml
alkaline urine
urease production

24
Q

Klebsiella

Appearance

A

Large mucoid colonies due to large capsule

25
Q

Klebsiella virulence factor

A 
Antiphagocytic Capsule
Type 1 pili: adhere to urinary
Type 3 pili: adhere to res. tract
Enterotoxin similar to ST, LT
-secretory diarrhea
26
Q

Helicobacter pylori

A

Gram - (most prevalent - in GI)
Oral to Oral contact
Slow
Found only in mucous overlying mucous cell in stomach

27
Q

H pylori Cancer

A

Down regulation of Somatostatin

Gastrin increases

Micro (11 decks)

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