Flashcards in 5.1 Antivirals Deck (11)
What are the types of influenza virus?
A - antigenic shift/drift, animal hosts, common and severe
B - no antigenic shift
C- uncommon, less severe
How do viruses replicate?
Attachment - to Sialic acic or neuraminic residue
Uncoating- H+ entry
What are M2 ion channel blockers?
Block the M2 receptor on the virus
Normally allows H+ entry which uncoats it allowing RNA etc to enter the cytoplasm
Examples of M2 blockers
ADRs of M2 blockers?
Confusion and Hallucination
Use M2 blockers when?
Influenza A only
What are Neuroamidase inhibitors?
Prevents neuroamidase which breaks down the residue bond when a viron buds off
What are the properties of Neuroamidase inhibitors?
Treats A and B
What are some ADRs of Neuroamidase inhibitors?
Nothing tooooo serious
Examples of N Inhibitors