5.1 Antivirals Flashcards Preview

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Flashcards in 5.1 Antivirals Deck (11):
1

What are the types of influenza virus?

A - antigenic shift/drift, animal hosts, common and severe

B - no antigenic shift

C- uncommon, less severe

2

How do viruses replicate?

Enter Blood
Attachment - to Sialic acic or neuraminic residue
Endocytosis
Uncoating- H+ entry
RNA/DNA/Protein replication
Budding

3

What are M2 ion channel blockers?

Block the M2 receptor on the virus
Normally allows H+ entry which uncoats it allowing RNA etc to enter the cytoplasm

Prevents REPLICATION

4

Examples of M2 blockers

Amantadine
Rimantadine

5

ADRs of M2 blockers?

GI symptoms
Hypotension
Confusion and Hallucination
Insomnia

6

Use M2 blockers when?

Influenza A only

7

What are Neuroamidase inhibitors?

Prevents neuroamidase which breaks down the residue bond when a viron buds off

Prevents BUDDING

8

What are the properties of Neuroamidase inhibitors?

High affinity
High potency
Treats A and B

9

What are some ADRs of Neuroamidase inhibitors?

GI
Headache
Nosebleed
Nothing tooooo serious

10

Examples of N Inhibitors

Oseltamivir
Zanamivir

11

Rarely what can happen with NIs?

Respiratory Depression
Bronchospasm