Diseases of the Upper GI: Pathology of the Esophagus Flashcards
The stratum basalis should not be more than ______ percent of the epithelial layer.
15
Sticking of pills can cause ___________.
esophagitis due to chemical irritation
What are some causes of esophagitis?
- Chemical injury (acids, alkalis, lye, alcohol, meds)
- Infection (candida, HSV)
- Immune-related diseases (EoE)
- Radiation (from cancer)
- Trauma
Nissen fundoplication is used to treat _______________.
refractory esophageal reflux; it involves wrapping part of the stomach around the LES to strengthen the sphincter and prevent reflux
PAS stains are used to identify ______________.
fungi
_______________ can lead to esophageal stricture.
Eosinophilic esophagitis
Mid-esophageal diverticula are associated with ____________.
TB infection in the mediastinum
Epiphrenic diverticula are associated with ______________.
hiatal hernias
What are Schatzki rings?
Esophageal strictures, most often due to GERD (thought to be protective)
Tracheo-esophageal fistulas can cause ___________.
recurrent pneumonia
In the U.S., the most common cause of esophageal varices is ______________; worldwide, however, it is _____________.
cirrhosis; schistosomiasis infection
Low-grade Barrett’s is characterized by the ____________ appearance.
“picket-fence” (elongated cells with stretched-out nuclei)
High-grade Barrett’s is characterized by _____________.
round nuclei with crowded glands
How is Barrett’s managed?
- Without dysplasia: 3 yr monitoring
- Low-grade dysplasia: 1 yr monitoring
- High-grade dysplasia: surveillance 3 mth; resection; ablation
Barrett’s can lead to _______-carcinoma.
adeno
