Pathology Case-Based Review

Question 1

Under biopsy, herpes simplex virus will display what histologic pattern?

Answer 1

Syncytial changes

Question 2

True or false: ulcerative colitis can cause strictures.

Answer 2

False. Only Crohn’s

Question 3

Although the lesions seen in ___________ are not neoplastic, having that syndrome puts you at increased risk for adenocarcinoma.

Answer 3

Peutz-Jeghers

Question 4

100% of people with FAP will get colon cancer before age ______.

Answer 4

30

Question 5

C. difficile is associated with ___________ diarrhea.

Answer 5

watery

Question 6

The 25-year risk of adenocarcinoma in those with IBD is ________.

Answer 6

10%

Question 7

Hyperplastic polyps are more common on which side of the colon?

Answer 7

Left

Question 8

Most forms of colorectal cancer are ___________.

Answer 8

sporadic (65% - 85%)

Question 9

Hereditary non-polyposis colon cancer tends to appear on which side?

Answer 9

The right

Question 10

What does desmoplastic mean?

Answer 10

Fibrotic

Question 11

What are the four pathways that lead to colon cancer?

Answer 11

Wnt/Beta-catenin
KRAS –MAPK
KRAS –PI3
Microsatellite instability

Question 12

True or false: almost 100% of people with HNPCC will develop colon cancer.

Answer 12

False-ish. It’s only 80%.