DIT White Board

Question 1

Volume of Distribution

Answer 1

Vd = D/C =Kg/Concentration = L
D = Amt of drug in IV form (or oral 100% bioavailability)
C = Concentration of drug in the plasma
**don’t forget to account for patient’s weight

Question 2

Clearance

Answer 2

CL = Rate of elimination of a drug/Plasma drug concentration
CL = 0.7 x Vd / T1/2
CL = K x Vd     (k = elimination constant)

Question 3

Loading Dose

Answer 3

LD = Css x Vd
Css = Concentration at steady state (target conc)
if Css is constant, only Vd will change MD

Question 4

Maintenance Dose

Answer 4

MD = Css x CL
if Css is constant, only CL will change MD
**will likely have to change from unit minutes to hours (how often they want it administered)

Question 5

Achieving 94% Loading/Elimination, T1/2

Answer 5

T 1/2:
1 -> 50%
2 -> 75%
3 -> 87.5%
4 -> 94%