UWorld Buzz Words / Key Features

Question 1

Lynch Syndrome

Answer 1

MT MSH2, MLH1 -> (mutS, MutL pr) - Colon CA

Causes abnormal nucleotide mismatch repair

Question 2

Fragile X Syndrome

Answer 2

small gap near tip of long arm of X chromosome (cytogenetic studies)
FMR1 gene MT

Question 3

Krukenberg Tumor: Histo

Answer 3

Signet ring cells with mucin displacing nucleus (primary GI CA that can met, esp ovaries -ex: adnexal masses)

Question 4

Renal Cell Carcinoma: Histo

Answer 4

clear cell type - nests of epithelial cells with abundant, clear cytoplasm. Separated by branching vascular tissue.

Question 5

Hodg Lymphoma: Histo

Answer 5

Reed-Sternberg Cells: “owl-eyes”-giant cells with bilobed nuclei or multiple nucleoli with prominent inclusion-like nucleoli

Question 6

Squamous Cell cancer: Histo

Answer 6

intercellular bridges between epithelial cells, keratin pearls are whorle shaped and from keratin of SCC

Question 7

Teratoma: Histo

Answer 7

subaceous and keratinaceous debris

Question 8

Lung CT sign shows reabsorption of necrotic tissue after a fungal infection with resolving neutropenia

Answer 8

“air-crescent sign” (ex: aspirgilosis)