GI 6 Flashcards
1
Q
Malabsorptive disorders are a result of
A
myriad of diseases that have malabsorption of nutrients as a consequence
2
Q
malabsorptive disorders: typically affect this
A
small intestine (where most nutrients are absorbed)
3
Q
malabsorptive disorders: conditions
A
- celiac disease
- infections
- short gut syndrome 2˚ to surgery
- structural defects
4
Q
What is the most common malabsorptive disorder?
A
celiac disease
5
Q
What is celiac?
A
- immune-mediated disorder
- triggered by exposure to gluten
6
Q
prevalence of celiac
A
~ 1% of population
7
Q
celiac risk factors
A
- other autoimmune disorders
- IgA deficiency
- genetic syndromes
- family hx
- DM I
- thyroiditis
8
Q
celiac disease pathogenesis: What happens when the small intestine is exposed to gluten?
A
- immune response triggered
- T cells aggregate into small intestine mucosa
- inflammatory response leads to destruction of intestinal cells
9
Q
celiac disease is linked to a higher risk of:
A
cancer
10
Q
celiac dz: s/s
A
- broad range (makes dx difficult)
- severe diarrhea, bloating, indigestion
- WL
- abd cramping
- nutrient deficiency
- long-term complications
11
Q
celiac dz: nutrient deficiency
A
- folate
- iron
- fat-soluble vitamins
- Vitamin B12
12
Q
celiac dz: long-term complications
A
- OP
- infertility
- coagulation abnormalities
- anemia
- neuro probs
13
Q
skin manifestations of celiac
A
dermatitis herpetiformis
