LEARN Flashcards

1
Q

as EDV increases

A

cardiac perfomance increases:

  • longer muscle
  • more cross-bridges formed
  • stronger contraction
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2
Q

as ESV increases

A

decrease in cardiac performance due to a decrease in cardiac output

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3
Q

venous return

A

rate of blood flow back to the heart

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4
Q

ejection fraction

A

=sv/edv

between 55-75%

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5
Q

left coronary artery divides into

A

circumflex artery and the left anterior artery

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6
Q

circumflex artery

A

back and top portion of the heart

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7
Q

left anterior artery

A

left ventricle - septum

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8
Q

coronary veins

A

takes oxygen poor blood back to the right atrium –> already used by the heart

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9
Q

angiotensin 2

A

causes vasoconstriction (increasing TPR) as well as increasing water retension

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10
Q

blood pressurw

A

CO x TPR

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11
Q

TPR

A

total peripheral resistance

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12
Q

RAAS

A

stimulates feelings of thirst

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13
Q

blood pressure

A

120/80

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14
Q

heart rate

A

60-100

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15
Q

ventricle muscle

A

trabecular carnage

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16
Q

cardiac muscle

A

heart

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17
Q

skeletal

A

lungs

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18
Q

smooth

A

GI

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19
Q

peak flow

A

persons maximum speed of expiration measured using a peak flow meter

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20
Q

vital capacity

A

maximum vol of air which can be expelled form the lungs, when deepest breath take (304 litres)

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21
Q

VO2 max

A

max rate at which heart, lungs and muscles effectivey use oxygen during exercise

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22
Q

BOHR shift occurs

A

presence of CO2

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23
Q

ventilation rate

A

12-20 breaths a min

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24
Q

hypoxic pulmonary vasoconstriction

A

areas of the lungs which are oxygen deficient will vasoconstrict- forcing more blood to areas of the lung which are rich in oxygen –> more efficient–> improves ventlation/perfusion ratio

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25
Q

2 cells which form red blood cells:

A

haematopoietic stems cells and progenitor stem cells

26
Q

pressure in pleural cavity

A

pressure slightly less than atmospheric –> means alveoli are inflated

27
Q

ppneumothorax

A

puncture in the pleura and air being introduced into the cavity- cause lung to collapse due to negative pressure not being generated

28
Q

resistance

A

diameter of airway –> expiratory problem

29
Q

compliance

A

lungs ability to stretch and expand

30
Q

low compliance

A

fibrosis

31
Q

high compliance

A

emphysema

32
Q

atmospheric pressure

A

760

33
Q

intrapulmonary pressure -within the lungs

A

760

34
Q

intrapleural pressure

A

756

35
Q

transpulmonary pressur

A

760-756= 5 mmHg

36
Q

complement mannon-binding

A

1) mast cell activation
2) opsonisation
3) chemotaxis

37
Q

antibodies and viruses

A

1) bind and neutralise

2) draw NK cells to virally infected cells

38
Q

leucoytes

A

a white blood cells: lymphocyte, granulocytes, monocyte

39
Q

which cells carry out phagocytosis

A

macrophages
neutrophils
dendritic

40
Q

C reactive protein

A

produced by the liver, a key marker for assessing inflammation and treatment progression

41
Q

classical pathway activated by

A

antigen-antibody complexes activating C1

42
Q

MB lectin pathway activated by

A

lectin binding to mannose on the pathogen surface

43
Q

alternative pathway activated by

A

pathogen surgaves

44
Q

PAMPs

A

pathogen associated molecule pattern

-recognised by pattern recognition receptors of the INNATE immune system

45
Q

IgA

A

milk–> specialised for defending body surfaces. also found in tears

46
Q

IgG

A

placental transfer

1) neutralisation of microbes and toxins
2) opsonisation of antigens
3) activate of classical pathway

47
Q

IgM

A

activation of classical pathway

48
Q

IgE

A

parasites (helminths)

49
Q

types of vaccine

A

1) whole dead or attenuated
2) parts of the pathogen
3) DNA coding for part of the organism

50
Q

main cells found in the lymph

A

lymphocytes

51
Q

lymphocytes

A

1) NK
2) cytotoxic
3) T cells
4) B cells

52
Q

CD 4T cells

A

T helper cells

  • Th1 -activate cytotoxic and NK cells
  • Th2 -B cells to plasma cells
53
Q

IL-17

A

fungi, bacteria and organ specific autoimmune disease

54
Q

innate cells (No! Mary Bought More Evil Devils)

A

neutrophil, monocyte/macrophage, basophil, mast, eoinsophil , dendritic

55
Q

adaptive

A

lymphoid cells e.g. NK, cytotoxic and B cells

56
Q

cells that are in both innate and adaptive system

A

dendritic

57
Q

myeloid precursor

A

innate

58
Q

lymphoid precursor

A

adaptive

59
Q

role of monocyte/ macrophages

A

phagocytosis
antigen presentation
cytokine production

60
Q

eoinsophils

A

inflammatory respons

61
Q

basophil

A

contains histamine - promotes blood flow to tissue and contains heparin –> prevents blood clotting