Peripheral Neuropathy

Question 1

Define peripheral neuropathy

Answer 1

Distal weakness and sensory loss of peripheries

Question 2

Causes of polyneuropathy

Answer 2

genetic

toxins - alcohol, thalium, drugs

metabolic - diabetes, CKD

Inflamattory - guillian barre, SLE, RA

infections - HIV,

Neoplasm

Vitamin deficiency - B12, thiamine, folic acid

Question 3

Investigations of peripheral neuropathy

Answer 3

Glucose (fasting)

ESR, CRP

FBC

U&Es

LFT

Vb12 and folate

CXR

HIV test

Question 4

Median nerve entrapment

Answer 4

Carpal tunnel syndrome

tingling and pain on palmar aspect of hand

sensory loss from thumb to lateral half of 4th finger

Question 5

Ulnar nerve entrapment

Answer 5

parasthesia on medial border of hand, wasting and weakness of hand muscles

sensory loss of medial palm till medial half of 4th finger

Question 6

Radial nerve entrapment

Answer 6

weakness of extension of wrist and fingers, often precipitated by abnormal sleep position

sensory loss of dorsum of thumb

Question 7

common peroneal nerve entrapment

Answer 7

foot drop or trauma to head of fibula

no sensory loss, may be dorsum of foot

Question 8

Lateral cutaneous nerve of the thigh entrapment

Answer 8

tingling and dyaseathesia on lateral border of thigh

sensory loss of lateral border of thigh

Question 9

what is dyaseathesia

Answer 9

abnormal unpleasant sensation felt on are of peripheral neuropathy

Question 10

Multifocal neuropathy (mononeuritis complex)

Answer 10

when multiple nerve roots, peripheral nerves, or cranial nerve lesions occur serially or concurrently

Question 11

polyneuropathy

Answer 11

clinical effects of generalized pathological process occur in the longest peripheral nerve first.

lower limbs before upper limbs

glove and stocking distribution and ascending