Acute liver disease Flashcards
1
Q
What is it?
A
Rapid development of hepatic dysfunction without prior liver disease
Any insult to a previously normal liver causing damage
2
Q
Duration
A
Less than 6 months
3
Q
Common causes
A
Viral hepatitis (A,B,C,D,E) CMV EBV Drugs - paracetamol Shock liver Cholangitis Alcohol Malignancy
4
Q
Rare causes
A
Budd Chiari
AFLP
Cholestasis
5
Q
Clinical features
A
None Jaundice Lethargy Nausea Anorexia Pain Itch Arthralgia
6
Q
Investigations
A
LFT - abnormal
US
Bloods (check for virus)
7
Q
Management
A
Rest Fluids Increase calorie intake - NG feeding may be indicated Itch - sodium bicarbonate/ urseodeoxycholic acid
8
Q
Outcomes
A
Complete restoration
Chronic liver disease
Death from acute liver failure
9
Q
Drug induced liver failure - features
A
Usually takes 6 weeks before you see a derangement in LFTs
10
Q
Fulminant hepatic failure
A
Acute liver failure
+ encephalopathy
11
Q
Fulminant hepatic failure
- management
A
Liver transplant
