SCC

Question 1

what is SCC

Answer 1

proliferation of atypical, transformed keratinocytes in the skin with malignant behaviour

Question 2

is SCC benign or malignant

Answer 2

malignant

Question 3

what are the different types of SCC

Answer 3

1 actinic keratosis (precursor to SCC)
2 Bowens disease
3 invasive SCC
4 metastatic SCC

Question 4

what are precursor lesions to SCC

Answer 4

actinic (sun-damage) keratosis

Question 5

what are non-melanoma skin cancers referred to as

Answer 5

keratinocyte cancers

Question 6

how common non-melanoma skin cancers (keratinocyte cancers)

Answer 6

most common skin cancer class

Question 7

what are the 2 most common keratinocyte cancers

Answer 7

1 BCC

2 SCC

Question 8

which normally is benign and which normally metastases between BCC and SCC

Answer 8

BCC - benign

SCC - malignant

Question 9

epi

Answer 9

common in sun exposed skin
middle age
men>women

Question 10

risk factors

Answer 10

fair skin
excessive sun exposure or UV exposure
radiation

Question 11

which form of UV radiation is most associated for formation of SCC

Answer 11

UV B (290-320nm)

Question 12

pathogenesis

Answer 12

mutations to DNA of keratinocytes which causes uncontrolled proliferation and transformation

Question 13

where is bowens disease confined to

Answer 13

outer layer of skin

Question 14

where has invasive SCC spread

Answer 14

into deeper layers of skin but not body

Question 15

where has metastatic SCC spread

Answer 15

into deeper layers of skin and body

Question 16

history

Answer 16

slow growing mass which is rough and scaly, on the skin which may be bleeding or crusting
often looks like a large wart and may have a raised crusted surface

Question 17

what is a keratoacanthoma

Answer 17

a rapidly growing dome shaped nodule with a central crater

Question 18

what is the first line investigation for SCC

Answer 18

biopsy which shows keratinocyte atypia

Question 19

what might there be a history of in SCC

Answer 19

skin cancer

Question 20

A 70-year-old previously healthy white man presents with multiple, hyperkeratotic, scaly papules on the face, scalp, and hands. Some papules have grown to become larger nodules that sometimes bleed and fail to heal. In the past he has had significant sun exposure including multiple blistering sunburns. Previously, he has had skin cancer on the face.

Answer 20

SCC