BCC Flashcards
def
common skin neoplasm
what is BCC related to
sunlight
was is BCC also known as
basal cell epithelioma as it rarely metastasises
epi
very common
increases with age
why is BCC more common in australia than the UK
associated with increased exposure to sunlight
aetiology
repetitive and frequent sun exposure
how does sunlight cause BCC
UV radiation induces DNA damage in keratinocytes
what is the most damaging form of UV light
290-320nm wavelength
what gene mutations are associated with BCC
p53
sonic hedgehog signalling cascade
what are risk factors for BCC
sun exposure
UV radiation +XRs
what do sunbeds increase the risk of
SCC and MM
but not BCC
what is basal cell naevus syndrome
AKA gorlin-goltz syndrome
autosomal dominant
broad face, rib deformities
history
a small firm raised swelling on the skin with visible blood vessels and rolled smooth edges
there may be a non-healing wound or scab on the swelling
how common is metastasis with BCC
uncommon
investigations
biopsy for dermatohistopathology
