PassMedicine Flashcards
what are the layers of the skin
epidermis
dermis + cutaneous nerves
subcutaneous layer
what are the layers of the epidermis
cornified (horny) layer
grannular layer
spinous layer
basal layer
what are there lots of in the spinous layer
keratinocytes
what are the four cells of the epidermis
keratinocytes (most common)
melanocytes
langerhans cells
merkel cells
what are melanocytes
pigment producing cells
where are melanocytes found
basal layer of epidermis
what is oncholysis
separation of nail from nail bed
what conditions are associated with oncholysis
psoriasis
RA
thyroid disease
what is the first line treatment for atopic dermatitis
emollients and topical steroids
causes of hirsuitism
PCOS
cushings
acromegaly
what drug can cause hair loss
warfarin (uncommonly)
what is acanthosis nigricans associated with
GI carcinoma
hodgkins lymphoma
thyroid disease
what sort of hypersensitivity reaction is seen in contact dermatitis
delayed IV
what does macular mean
distinch red spots on skin
what is pyoderma gangrenosum
rare skin condition which causes tissue to become necrotis leading to painful ulcers
what is dermatitis herpetiformis
a chronic itchy blistering skin condition
what is dermatitis herpetiformis associated with
coeliacs
what are causes of generalised hypopigmentation
phenylketonuria
albinism
hypopituitarism
what are causes of localised hypopigmentation
vitiligo
leprosy
what is pyoderma gangrenosum associated with
CD
what is lupus pernio associated with
sarcoidosis
what is characteristic of lupus pernio
blue-red nodular lesions on nose
what is a tight white ring around the tip of the foreskin and phimosis likely to be
lichen sclerosis
what sort of reaction is erythema multiforme
a hypersensitivity reaction
what is erythema multiforme major associated with
mucosal involvement