MedEd Flashcards
A 1-year-old boy is brought to the GP clinic with a dry, scaly, erythematous rash on his cheeks and chin. He appears systemically well, and is not crying, however he repeatedly tries to move his hand to the rash. On close inspection of the rash, you also notice some small excoriation marks. The rash is limited to the face, with no spread to the limbs or trunk. On questioning, the father suffers from asthma. Select the likely diagnosis:
Parvovirus B19 infection Atopic dermatitis Plaque psoriasis Contact dermatitis Impetigo
Atopic dermatitis
A 22-year-old woman presents to her GP complaining of a moderately itchy rash present on both arms. She is systemically well. The rash is plaque-like in appearance, with well-defined edges and a silvery surface, present on the extensor surfaces of both elbows. She reports also noting a scaly, itchy rash on her scalp. Which of the following is not associated with this disease:
Arthritic pain Onycholysis Nail pitting Family history of asthma Rashes on the palms and soles
Family history of asthma
A 78 year old diabetic woman with a history of poorly-healing leg ulcers presents to her GP with a painful skin rash, following a 5-day course of topical antibiotic treatment for a skin infection. The rash appears blistered, with several vesicles present over the site of the previous skin infection, some of which have burst on examination, releasing clear fluid. The patient moans that the drug didn’t clear her infection. What is the likely diagnosis?
Erythema multiforme Pemphigus Secondary infection with S. aureus Allergic contact dermatitis Irritant contact dermatitis
Allergic contact dermatitis
what protein is decreased in atopic dermatitis
fillagrin
what is fillagrin
a protein responsible for keeping moisture in the stratum corneum and for maintaining the skins slightly acidic pH
what sort of hypersensitivity reaction is associated with atopic dermatitis
type I (immediate hypersensitivity with igE)
what sort of condition is psoriasis
immune-mediated inflammatory condition
who does psoriasis commonly affect
young adults
which inflammatory cytokines are associated with psoriasis
Il-1B, TNF-a, IL-17a
what are features of plaque psoriasis
symmetrical scaly plaques which are salmon pink with silver scales
where is plaque psoriasis commonly found
extensor surfaces
what are features of guttate psoriasis
“gutta” means teardrop
small red scaly ‘teardrops’ across the body
commonly following a URTI with strep
what is erythroderma
dry red skin across the body
what are triggers for erythrodermic psoriasis
drugs (anti-malarias, lithium, BBs), infections, low calcium, cessation of steroids
what is the treatment for erythrodermic psoriasis
hospitalisation
IV fluids, temp regulation, emollients
what sort of hypersensitivity reaction is allergic contact dermatitis
type IV (delayed)
what is characteristic of parvovirus B19
‘slapped cheek’ rash and also causes red cell aplasia
what is red cell aplasia
erythrocytes stop maturing - causes normocytic anaemia
what is pemphigus
a bullous disease where large bullae result from separation of epidermis from the dermis
what sort of condition is pemphigus
autoimmune
A 65 year old man presents with what he describes as a strange lump on the side of his nose. He says he first noticed it 4 months ago, but didn’t go to his GP as he spends 6 months of the year in the Cayman islands where his tax-free earnings live. You notice he has many freckles on his face and chest. The lump is a skin-coloured, round, well-circumscribed nodule with rolled edges and a pearly appearance, and blood vessels crossing its surface. Select the likely diagnosis:
Basal cell carcinoma Fluid-filled cyst Keratoacanthoma Malignant melanoma Squamous cell carcinoma
Basal cell carcinoma
A 55-year old Australian man attends your dermatology clinic worried about a mole on his back. He says his wife spotted it when on the beach, and that it appears bigger than when she first noticed it 6 weeks ago. Upon examining his back, you notice more than 10 moles. The mole of concern is different to the others, as it has irregular, poorly-circumscribed edges and variable pigmentation, and is considerably larger than its siblings. Its appearance under the dermatoscope worries you. Select the most appropriate next step:
Immunohistochemical staining Ultrasound scan Partial biopsy Total excision 5-fluorouracil cream
Total excision
A 68 year old man with a history of previous BCC comes to your GP rapid access clinic, concerned about a sudden growth on his right ear. He says it started less than two weeks ago as a small pimple, which he tried to pop but couldn’t, and is now the size of an olive (2cm). The nodule is spherical, skin coloured and ulcerated, with a scaly core. Select the likely diagnosis:
Rapidly growing BCC Keratoacanthoma Bowen’s disease HPV-induced wart Squamous cell carcinoma
Keratoacanthoma
