Pancreatic Cancer Flashcards
what is the most common pancreatic cancer
pancreatic ductal adenocarcinoma
what is the progression to pancreatic cancer
from pre-invasive pancreatic intraepithelial neoplastic lesions to invasive
what are precursor forms of pancreatic cancer
pre-invasive intraepithelial neoplasm
intraductal papillary mucinous neoplasm
mucinous systic neoplasm
epi
poor prognosis
risk factors
smoking
what inherited conditions increase risk of pancreatic cancer
hereditary pancreatitis
Peutz-Jeghers syndrome
HNPPC (lynch syndrome)
what is peutz-jeghers syndrome
autosomal dominant condition
multiple polyps originating from the GI tract
what are people with peutz jeghers syndrome at increased risk of
pancreas cancer
lung cancer
ovary + breast cancer
where are most pancreatic tumours found
head of pancreas
risk factors
smoking
FHx of pancreatic cancer
cancer syndomes such as hereditary pancreatitis and peutz jeghers syndrome
how does pancreatic cancer present
elderly presents with:
upper abdominal pain or back pain if retroperitoneal metastases
weight loss and loss of appetite
jaundice
what is courvoisiers sign
painless palpable gallbladder and jaundice
what is trousseaus sign
in pancreatic cancer
migratory thromboembolism with thrombosis
why can pancreatic cancer present with jaundice
head of pancreas obstructs common bile duct
what tumour marker is associated with pancreatic cancer
CA19-9
