Chapter 10 Epithelial pathology

Question 1

What is a benign proliferation of stratified squamous epithelium?

Answer 1

-Squamous papilloma

Question 2

What causes squamous papilloma?

Answer 2

-Human papillomavirus type 6 and type 11

Question 3

What type of virus is HPV?

Answer 3

-DNA Papovavirus

Question 4

T/F Squamous papilloma has extremely low virulence and infectivity rate

Answer 4

True

Question 5

What is virulence?

Answer 5

-Ability of virus to overcome body’s defenses and cause disease

Question 6

What is infectivity?

Answer 6

-Ability to establish infection from one person to another horizontally

Question 7

What are the sites of predilection of Squamous papilloma?

Answer 7

• Tongue
• Lips
• Soft palate

Question 8

T/F Papillomas can be pedunculated

Answer 8

True

Question 9

What are the differential diagnosis that appear like squamous papilloma?

Answer 9

• Verruca vulgaris
• Condyloma acuminatum
• Verruciform xanthoma

Question 10

What is a common wart known as?

Answer 10

-Verruca Vulgaris

Question 11

What HPV types cause Verruca vulgaris?

Answer 11

• 2
• 4
• 6
• 40

Question 12

What HPV types are associated with squamous papilloma?

Answer 12

• 6

- 11

Question 13

T/F Verruca vulgaris is not contagious

Answer 13

False

-It is contagious

Question 14

What does an oral verruca vulgaris appear as?

Answer 14

-White pebbly surface

Question 15

What is Condyloma Acuminatum aka?

Answer 15

-Venereal wart

Question 16

T/F Condyloma acuminatum is considered a sexually transmitted disease

Answer 16

True

Question 17

What HPV types cause Condyloma acuminatum?

Answer 17

• 6 -most common
• 11- most common
• 16
• 18
• 31

Question 18

What is the size of condyloma acuminatum?

Answer 18

-1-1.5 cm

Question 19

If the condyloma acuminatum are HPV type 16 or 18 found in the anogenital area what are they at increased risk for?

Answer 19

-Malignant transformation to squamous cell carcinoma

Question 20

What is multifocal epithelial hyperplasia aka?

Answer 20

-Heck’s disease

Question 21

What types of HPV cause Heck’s disease (multifocal epithelial hyperlpasia?

Answer 21

• HPV -13

- HPV 32

Question 22

What type of patient does Heck’s disease appear in?

Answer 22

-Children but it lasts for life

Question 23

What are benign localized proliferations of respiratory mucosa known as?

Answer 23

-Sinonasal papillomas

Question 24

What are the three distinct patterns of sinonasal papillomas?

Answer 24

• Fungiform
• Inverted
• Cylindrical cell

Question 25

What type of virus is Molluscum Contagiosum?

Answer 25

-DNA poxvirus

Question 26

What does the histopathology of Molluscum contagiosum have?

Answer 26

-Henderson-Paterson bodies

Question 27

What is characterized by lipid-laden histiocytes in the epithelium?

Answer 27

-Verruciform Xanothoma

Question 28

Seborrheic keratosis is extremely common in what population?

Answer 28

-Older people

Question 29

What is a form of Seborrheic keratosis that occurs in 30% of African Americans?

Answer 29

-Dermatosis papulosa nigra

Question 30

What is the sudden appearance of numerous seborrheic keratoses with pruritus called and has been associated with interal malignancy?

Answer 30

-Leser-Trelat sign

Question 31

What is Ephelis aka?

Answer 31

-Freckle

Question 32

What causes ephelis to become for pronounced?

Answer 32

-Sun exposure

Question 33

What is a benign brown macule resulting from chronic UV light damage to the skin?

Answer 33

-Actinic Lentigo

Question 34

If the person has freckles that don’t become more pronounced from sun exposure what is it called?

Answer 34

-Actinic Lentigo

Question 35

What is a benign cutaneous melanocytic hyperplasia known as?

Answer 35

-Lentigo simplex

Question 36

What is a hormonally driven hyper-pigmentation of sun-exposed skin of the face known as?

Answer 36

-Melasma

Question 37

What is Melasma classically associated with?

Answer 37

-Pregnancy