antihypertensives Flashcards
htn is a chronic disorder affecting ___ million adults in the US
50-60
HTN inc risk of?
MI, HF, cerebral infarction and hemorrhage
renal disease
what are the 2 main determinants in BP?
CO (systolic pressure) and peripheral vascular resistance (diastolic pressure)
what is auto regulation?
ability of body tissues to regulate own blood flow
what are some nutritional needs of tissue that cause auto regulation?
lack of o2
cellular metb by-products
what is the response to hypotension?
SNS stimulated
adrenal medulla secretes epi and norepinephrine
angiotensin II and aldosterone are formed
kidneys retain fluid
bp is inc
what is the response to htn?
inc renal secretion
fluid loss dec circulating vol which
dec CO which dec arterial BP which dec BP
what are the tissue factors important in auto regulation?
histamine, bradykinin, serotonin, and prostaglandins
what is defined as htn? (values)
Systolic pressure >140 mm Hg
Diastolic pressure >90 mm Hg
there is primary and secondary htn- what is the % of primary?
90-95
what does secondary htn result from?
renal, endocrine, or CNS disorders or from meds
normal bp values?
Normal = systolic <120 and diastolic 80–89
pre-htn values?
systolic 120–139 or diastolic 80–89
stage 1 htn?
systolic 140–159 or diastolic 90–99
stage 2 htn?
systolic >160 or diastolic >100
