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DT 3 > 1,4-5. Vascular Path,5 > Flashcards

1,4-5. Vascular Path,5 Flashcards

1
Q

wt is the composition of a vulnerable atherosclerotic plaque?

A

thinner cap

large lipid core

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2
Q

arteries affected by giant cell vasculitis?

wt part of artery?

A

temporal, opthalmic

elastic intima

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3
Q

most common cause of thoracic aortic aneurysm?

A

HTN/cystic medial degeneration

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4
Q

pt presents with malignant hypertension,

underlying cause?

A

hyperplastic arteriolosclerosis

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5
Q

vasculitis with fragmentaiton of neutrophils

A

microscopic polyangiitis

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6
Q

2 symptoms of giant cell arteritis?

A

jaw claudicaiton

headache

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7
Q

2 asscoiationgs w aortic dissection?

A

HTN and inherited CT disorders

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8
Q

df true aneurysm?

A

abnormal dilation

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9
Q

wc vasculitis can cause blindness? why?

A

giant cell arteritis due to occlusion of the opthalmic artery

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10
Q

vasculitis associated with men who are heaving smokers?

wt in seen pathologically?

A

Buerger Disease (thromboangiitis obliterans)

Segmental thrombosis and microabsesses

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11
Q

wc vasculitis can cause renal microaneurysms?

wt is a unique GI symptom of this disease?

A

Polyarteritis nodosa

Melena (blood in GI tract –> black stool)

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12
Q

complication of kawasaki syndrome?

A

coronary aneurysms

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13
Q

most common cause of abdominal aortic aneurysm?
most common location?
presentation?

A

atherosclerosis

distal to renal arteries

pulsating abdominal mass

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14
Q

cause of false aneurysm?

A

defect in vascular wall –> hematoma

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15
Q

2 symptoms/signs of aortic dissection?

A

sudden chest pain radiating to back

unequal BP in arm

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16
Q

2 conditions associated with MPA-ANCA/p-ANCA?

A

Churg-Strauss

Microscopic polyangitis

17
Q

df type A aortic dissection?

type B?

A

A - involves ascending aorta

B - descending aorta

18
Q

4 arteries most affected by atherosclerosis?

A

AA > coronary > popliteal > internal carotid

19
Q

4 modifiable risk factors for atherosclerosis?

A

hyperlipidemia
HTN
Cigs
DM

20
Q

2 complications of aortic dissection rupture?

A

cardiac tamponade

hemothorax

21
Q

2 types of ateriorolosclerosis?

wt causes each?

A

hyaline - mild, chronic htn

hyperplastic - malignant accelerated htn

22
Q

condition associated with PR3-ANCA/c-ANCA?

A

Granulomatosis with polyangitis

23
Q

steps to Intimal thickening?

A

SMCs migrate into intima and become proliferative (rather than contractile). they then synthesize ECM.

24
Q

wt cells in the vasculature are responsible for synthesis of collagen, elastin and proteoglycans?

A

SMCs

25
Q

wc vasculitis is known as the pulseless disease?

artery affected?

A

Takayasu vasculitis

Aortic arch

26
Q

vasculitis associated with coronary artery aneurysoms?

A

Kawasaki

27
Q

vasculitis associated with gangrene and amputation?

A

Buerger disease ( thromboangiitis obliterans)

28
Q

cause of aortic dissection?

A

intimal tear –> false lumen

29
Q

wt is the earliest lesion in atherosclerosis?

cell causing?

A

fatty streak

lipid-filled foamy macrophages

30
Q

wc vasculitis has GI symptoms?

complication?

A

PAN

microaneurysm

31
Q

vasculitis associated w palpable purpura?

A

microscopic polyangiitis

32
Q

2 main strucutures of atherosclerotic plaques? components of each

A

Fibrous cap - SMCs, collagen

Lipid core - cholesterol, foam cells, necrotic debris, fibrin

33
Q

wt ateries are affected by artiosclerosis?

A

elastic and muscular arteries

34
Q

wc vasculitis is commonly seen in HepB pts?

A

Polyarteritis nodosa

35
Q

Triad of polyangiitis with granulomatosis?

A

Respiratory involvement
focal necrotizing vasculitis of small vessels
renal disease

36
Q

wt characterizes monckeberg arteriosclerosis?

A

ring like calcifications in media of muscular arteries

37
Q

vasculitis seen in asian children <4 yo?
5 symotoms?
2 drugs to tx?

A

Kawasaki

Cunjunctival injection
Rash
Adenopathy
Strawberry Tongue
Hand-foot changes
fever (CRASH and burn)

IV IGs and aspirin

38
Q

4 presentations of Churg-strauss?

wt would be found in serum?

A

asthma, skin nodules, wrist/foot drop, eosinophilia

anti-meloperoxidase (MPA-ANCA/p-ANCA)

39
Q

5 pathogenesis of aneurysims?

A 
inflammaitn
HTN
atherosclerosis
CT disorders
Cystic medial degeneration

DT 3 (26 decks)

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