18. Dieuretics

Question 1

MOA of acetazolamide?
location?
2 uses?

Answer 1

Carbonic anhydrase inhibitor

proximal tubule

glaucoma and motion sickness

Question 2

MOA of spironolactone and eplerenone?

location

Answer 2

competitively inhibit aldosterone binding

late distal tubule and collecting duct

Question 3

name 4 K sparing diuretics?

Answer 3

spironolactone
eplerenone
triamterene
amiloride

Question 4

Diuretic of choice in hepatic cirrhosis pts?

Answer 4

Spironolactone

Question 5

MOA of thiazides?
location?
major AE?

Answer 5

inhibit sodium-chloride cotransporter at distal tubule

hypokalemia AE

Question 6

name 4 loop diuretics?

Answer 6

furosemide
bumetanide
torsemide
ethacrynic acid

Question 7

pt presents with edema, class of diuretic to used?

Answer 7

Loop diuretics

Question 8

class of diuretics with ototoxicity?

Answer 8

Loops

Question 9

MOA of Loop diuretics?

location

Answer 9

Inhibit Na-K-2Cl cotransporter in ascending limb of loop of henle

Question 10

diuretics with alterered hormonal activity (gynecomastia/menstrual probs)?

Answer 10

spironolactone

eplerenone

Question 11

MOA of osmotic diuretics?

name one?

Answer 11

filtered at glomerulus but poorly absorbed. as they are excreted, water is also.

Mannitol

Question 12

wc class of diuretics dec. Ca excretion?
wc increases?

Answer 12

thiazides dec. Ca excretion

loops inc. Ca excretion

Question 13

wc diuretic should be used in pts with GFR < 30?

wc will not work?

Answer 13

Loops

Thiazides dont work