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DT 3 > 31. Glomerular Diseases > Flashcards

31. Glomerular Diseases Flashcards

1
Q

5 symptoms of nephritic syndromes?

cause?

A 
hematuria
RBCs in urine
Azotemia
oliguria
HTN

Inflammation

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2
Q

4 symptom of nephrotic syndromes?

cause?

A

proteinuria
hypoalbuminemia
edema
hyperlipidemia

increased basement membrane permeability

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3
Q

child presents 2 weeks post strep infection w edema and cola colored urine, diagnosis?
pathogenesis?
wt is seen on EM?

A

postinfectious glomerulonephritis
immune complex
subepithelial humps

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4
Q

wr is seen on LM in RPGN?
cells causing?

wt is seen on EM

A

Crescents
parietal epithelial cells

Ruptures in GBM

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5
Q

cause of type 1 RPGN? IF?

A

anti-GBM antibodies (good pasture)

linear IF

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6
Q

cause of type 2 RPGN? IF?

A

immune complex

granular

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7
Q

cause of type 3 RPGN? IF?

A 
pauci immune (polyangiitises)
no IF
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8
Q

pt presents coughing up blood,

diagnosis of glomerular disease?

A

Type 1 RPGN (good pasture)

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9
Q

glomerular disease w spike and dome on EM?
location?
LM?

A

Membranous GN
subepithelial
capillary and GBM thickening

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10
Q

2 diseases w effacement of foot processes? wc responds well to steroids?

A 
minimal change (steroids)
focal segmental glomerulosclerosis
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11
Q

cause of FSGN?

LM?

A

epithelial damage

focal, segmental slerosis and hyalinaztion

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12
Q

glomerular disease w tram -track appearance?
wt stains IF?
pathogenesis of type 1?
type 2?

A

membranoproliferative GN

C3

immune complexes, classical and alternative pathway

alternative pathway

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13
Q

glomerular disease w basket weave GBM appearance on EM late in disease?

cause?

2 symptoms?

wt is seen early in disease?

A

Alport syndrome

abnormal collagen IV

deafness
eye disorders

early - GBM thinning

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14
Q

3 characteristics of chronic glomerulonephritis?

A

inflammation
hyalinized sclerotic vessels
atrophy of tubules

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15
Q

disease similair to IgA nephropathy?

A

Henoch-Schoenlein Purpura

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16
Q

wt causes diabetic nephropathy?

A

hyperglycemia –> alterations to GB

17
Q

glomerular disease w IC deposits in mesangium?

wt procedes the disease?

A

IgA nephropathy

UTI, GII, RI

18
Q

disease with subendothelial deposits on EM?

pathogenesis?

A

MPGN type 1

immune complexes, classical and altrnative complement

19
Q

2 glomerular diseases w subepithelial EM features? wt do they look like?

A

postinfectious GN - humps

membranous GN - spike and dome

DT 3 (26 decks)

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