Antibiotics-General

Question 1

When do bactericidal antibiotics have an advantage?

Answer 1

1. Endocarditis
2. Meningitis
3. Febrile neutropenia

Question 2

Which antibiotics have excellent oral bioavailability?

Answer 2

1. Amoxicillin
2. Cephalexin-Cephalosporins 1st gen
3. Quinolones
4. TMP-SMX
5. Tetracyclines
6. Chloramphenicol
7. Clindamycin
8. Fluconazole
9. Metronidazole

Question 3

Which antibiotics have good oral bioavailability?

Answer 3

1. Beta-lactams

2. Macrolides

Question 4

Which antibiotics have bad oral bioavailability?

Answer 4

1. Glycopeptides (vancomycin)

Question 5

Which antibiotics are concentration-dependent killing and must be give in infrequent, high doses ?

Answer 5

1. Aminoglycosides

2. Quinolones

Question 6

Which antibiotics are time-depending killing and must be give at frequent intervals, low doses?

Answer 6

1. Penicillins
2. Cephalosporins
3. Macrolides
4. Lincosamides
5. Tetracyclines

Question 7

Which antibiotics exhibit post-antibiotic effect? What is this effect?

Answer 7

Inhibitors of protein and nucleic acid synthesis:

1. Aminoglycosides
2. Tetracyclines
3. Macrolides
4. Lincosamides
5. Fluoroquinolones
6. Rifampin

Persistent suppression of bacterial growth after a brief (1-2 hr) exposure of bacteria to an antibiotic even in the absence of host defense mechanisms.