36. Cancer chemotherapy III (Topoisomerase inhibitors. Inhibitors of mitotic spindle)

Question 1

Which are the groups of drugs?

Answer 1

• Topoisomerase I inhibitors:
  
  • Topoisomerase I inhibitors (Camptothecins)
  • Topoisomerase II inhibitors
    
    • Anthracyclines
    • Anthracenediones
    • Epidophyllotoxins
• Inhibitors of mitotic spindle:
  
  • Taxane derivatives
  • Vinca alkaloids

Question 2

Which are the topoisomerase I inhibitors?

Answer 2

Camptothecins:

• Irinotecan
• Topotecan

Question 3

Which are the topoisomerase II inhibitors?

Answer 3

• Anthracyclines:
  
  • Doxorubicin
  • Epirubicin
  • Daunorubicin
  • Idarubicin
• Anthracenediones:
  
  • Mitoxantron
• Epidophyllotoxins:
  
  • Etoposide

Question 4

Which are the taxane derivatives of the inhibitors of the mitotic spindle?

Answer 4

• ​Paclitaxel
• Docetaxel
• Cabazitaxel

Question 5

Which are the vinca alkaloids inhibitors of the mitotic spindle?

Answer 5

• ​Vincristine
• Vinblastine
• Vinorebline​

Question 6

Which are the other inhibitors of the mitotic spindle?

Answer 6

Estramustin phosphate