3/18

Question 1

biochemistry in Huntingtons

Answer 1

gain of function mutation in CAG repeats that leads to deacetylation of histones

Question 2

defective neurotransmitter in Alzeimers

Answer 2

acetylcholine in nucleus basalis

Question 3

lab values in hypoaldosteronism

Answer 3

• high sodium
• low potassium
• low bicarb (H+ is no longer secreted - metabolic acidosis)
• high chloride to balance lost bicarb

Question 4

triad in VIPoma

Answer 4

• watery diarrhea (increase in cAMP)
• hypokalemia (secretion of K)
• achlorhydria (inhibits gastric acid secretion)

Question 5

paraneoplastic syndrome in squamous cell carcinoma

Answer 5

PTHrP

Question 6

ambiguous genitalia with maternal virilization

Answer 6

aromatase deficiency (to many androgens make it to mom)

Question 7

reactions that require B6

Answer 7

transaminase (remember that thiamine is for transketolase)

Question 8

hepatitis B replication

Answer 8

• semi double stranded DNA to RNA - reverse transcription back to DNA

Question 9

NK cells are activated by…..

Answer 9

gamma interferon and IL12

Question 10

fibroblast migration and proliferation are controlled by….

Answer 10

PDGF and TGF-beta

Question 11

poorly vascularized peripheral compartment

Answer 11

skeletal muscle, bone and fat

- for lipophilic drugs