Natural Killer cells Flashcards
1
Q
Lymphocyte member of innate immunity
A
Natural Killer Cell (NK cell)
2
Q
Target of NK cells
A
Virally infected cells and tumor cells
3
Q
Mechanism NK cells induce apoptosis
A
Use perforin and granzymes to induce apoptosis
4
Q
Cytokines that increase activity of NK cells
A
IL-2, Il-12, IFN-a, IFN-b
5
Q
Signal that induces NK cell to kill target cell
A
Exposure to non-specific activation signal and/or absence of MHC-I on target cell
6
Q
NK cell binds how to target cell
A
Antibody-dependent cell-mediated cytotoxicity (CD16 on NK cell binds to Fc region of bound Ig on target cell)
