CVR 35

Question 1

Toxicity depends on

Answer 1

substance
dose
exposure time
method of exposure
the individual

Question 2

Which layer of skin is responisble for absorbition

Answer 2

stratum corneum (epidermis) then dermis

Question 3

How is paracetamol metabolized

Answer 3

metabolized to a free radical that depletes gluthione following excess ingestion. N acetycholcysteine is a gluthionone precursor and is used in an overdose.

Question 4

What is LD 50
LOAEL
NOAEL

Answer 4

LD 50 is death in 50%
NOAEL is border between healthy and sick
NOAEL is border between no effect and effect

Question 5

Phases of drug trials

Answer 5

phase 1 = volunteers rising dose tolerance

2 = dose finding

3 = definitive findingswithin patient groups

4 = post approval studies