08 - Chemotherapy Flashcards
enfuvirtide
fusion inhibitor
gp41 blocker
target step: attachment to host
AZT (zidovudine)
NRTI (nucleotide reverse transcription inhibitor)
thymidine analog
target step: reverse transcription
lamivudine
NRTI (nucleotide reverse transcription inhibitor)
cytidine analog
target step: reverse transcription
nevirapine
NNRTI (non-nucleotide reverse transcription inhibitor)
allosteric modulation
targets step: reverse transcription
indinavir
protease inhibitor
competitive inhibitor for active site
target step: maturation of virons
penicillin
cell wall synthesis inhibitor (bactericidal)
beta-lactams
block transpeptidase
vancomycin
cell wall synthesis inhibitor (bactericidal)
non-beta-lactams
block peptidoglycan synthesis
tetracycline
protein synthesis inhibitor (bacteriostatic)
inhibit 30S ribosome subunit
chloramphenicol
protein synthesis inhibitor (bacteriostatic)
inhibit 50S ribosome subunit
sulfonamides
folate synthesis inhibitor (bacteriostatic)
competes with PABA
metronidazole
nucleic acid synthesis inhibitor (bacteriocidal)
quinolones
nucleic acid synthesis inhibitor (bacteriocidal)
polymyxins
increases cell permeability (bacteriocidal)
cisplatin
alkylating agents
DNA intercalators
inhibit DNA replication
5-FU (5-fluorouracil)
anti-metabolites pyrimidine analog (also folate, purine)