Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pathophysiology 1 MCQ > Atherosclerosis > Flashcards

Atherosclerosis Flashcards

1
Q

Which is true of the following statements?
Cholesterol molecules are located on the surface of lipoproteins
Apoproteins are located in the nuclei of lipoproteins
Triglycerides and cholesterol esters are located in the nuclei of lipoproteins
Lipoproteins are coated by a phospholipid bilayer

A

Cholesterol molecules are located on the surface of lipoproteins

Triglycerides and cholesterol esters are located in the nuclei of lipoproteins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Which is FALSE of the following statements?
Cholesterol molecules are located on the surface of lipoproteins
Apoproteins are located in the nuclei of lipoproteins
Triglycerides and cholesterol esters are located in the nuclei of lipoproteins
Lipoproteins are coated by a phospholipid bilayer

A

Apoproteins are located in the nuclei of lipoproteins

Lipoproteins are coated by a phospholipid bilayer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Functions of apoproteins:
Stabilization of lipoprotein structure
Regulation of receptor binding of lipoproteins
Potential activation of lipoprotein metabolism enzymes
Potential inhibition of lipoprotein metabolism enzymes

A

Stabilization of lipoprotein structure
Regulation of receptor binding of lipoproteins
Potential activation of lipoprotein metabolism enzymes
Potential inhibition of lipoprotein metabolism enzymes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q 
Choose the correct order of lipoproteins according to increasing density
HDL-LDL-IDL-VLDL-CHY
LDL-IDL-VLDL-HDL-CHY
VLDL-CHY-HDL-LDL-IDL
CHY-VLDL-IDL-LDL-HDL
CHY-IDL-VLDL-LDL-HDL
A

CHY-VLDL-IDL-LDL-HDL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q 
Lipoproteins rich in triglycerides:
LDL-IDL
HDL-IDL
HDL-LDL
CHY-LDL
CHY-VLDL
A

CHY-VLDL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q 
Lipoproteins rich in cholesterol:
VLD-IDL
CHY-IDL
HDL-LDL
CHY-LDL
CHY-VLDL
A

HDL-LDL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q 
Which lipoprotein plasma level is the most frequently elevated in diabetes mellitus?
CHY-VLDL-LDL
VLDL-HDL
LDL-CHY
VLDL-CHY
CHY-IDL
A

CHY-VLDL-LDL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q 
Which lipoprotein plasma level is the most frequently decreased in diabetes mellitus?
CHY
VLDL
LDL
HDL
IDL
A

HDL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q 
Which lipoprotein plasma level is the most frequently elevated in obesity?
CHY-VLDL-LDL
VLDL-HDL
LDL-CHY
VLDL-CHY
CHY-IDL
A

CHY-VLDL-LDL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q 
Which lipoprotein plasma level is the most frequently elevated in hypothyrosis?
CHY
VLDL
LDL
HDL
IDL
A

LDL

IDL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q 
Which lipoprotein plasma level is the most frequently elevated in nephrosis syndrome?
CHY
VLDL
LDL
HDL
IDL
A

CHY
VLDL
LDL

IDL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q 
Optimal value of serum tryglyceride (TG):
< 1,7 mmol/l
2,3-5,6 mmol/l
3,0-4,5 mmol/l
4,1-4,9 mmol/l
5,0-6,5 mmol/l
A

< 1,7 mmol/l

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q 
Apo B-48 is present in the following lipoproteins:
IDL
LDL
VLDL
CHY
A

CHY

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Which is true of the following statements?
LDL-receptors are located on the surfaces of liver and most other cells
Binding to LDL-receptors is regulated by apo B-100 and apo E
In man, approximately 70% of LDL is taken up in the liver and 30% in extrahepatic tissues
The main function of LDL is to transport the high energy content triglyceride

A

LDL-receptors are located on the surfaces of liver and most other cells
Binding to LDL-receptors is regulated by apo B-100 and apo E
In man, approximately 70% of LDL is taken up in the liver and 30% in extrahepatic tissues

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Which is FALSE of the following statements?
LDL-receptors are located on the surfaces of liver and most other cells
Binding to LDL-receptors is regulated by apo B-100 and apo E
In man, approximately 70% of LDL is taken up in the liver and 30% in extrahepatic tissues
The main function of LDL is to transport the high energy content triglyceride

A

The main function of LDL is to transport the high energy content triglyceride

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Which is true of the following statements?
HDL is exclusively formed in hepatocytes
Protein constituents of apo C an apo E are synthesized in the liver and associate to HDL particles in the circulation
HDL also contains apo B-48
The nascent discoid shaped HDL consist of cholesterol, phospholipid and apo A

A

Protein constituents of apo C an apo E are synthesized in the liver and associate to HDL particles in the circulation

The nascent discoid shaped HDL consist of cholesterol, phospholipid and apo A

17
Q

Which is FALSE of the following statements?
HDL is exclusively formed in hepatocytes
Protein constituents of apo C an apo E are synthesized in the liver and associate to HDL particles in the circulation
HDL also contains apo B-48
The nascent discoid shaped HDL consist of cholesterol, phospholipid and apo A

A

HDL is exclusively formed in hepatocytes

HDL also contains apo B-48

18
Q

Cardiovascular protective functions of HDL particle:
Enhances the peripheral uptake of LDL particles by its apo E content
Enhances the receptor mediated endocytosis of CHY- and VLDL-remnant particles by its apo C and apo E content
Macrophag presence is enhanced in the vessel wall by the anti-apoptotic effect of HDL
HDL enhances the PGI2 production of endothelial cell thereby inhibiting platelet adhesion

A

Enhances the peripheral uptake of LDL particles by its apo E content
Enhances the receptor mediated endocytosis of CHY- and VLDL-remnant particles by its apo C and apo E content

HDL enhances the PGI2 production of endothelial cell thereby inhibiting platelet adhesion

19
Q

Cardiovascular protective functions of HDL particle:
Enhances the peripheral uptake of LDL particles by its apo E content
Macrophag presence is decreased in the vessel wall as a result of HDL-effect
HDL has anti-oxidant activity
HDL decreases the receptor mediated endocytosis of CHY- and VLDL-remnant particles

A

Enhances the peripheral uptake of LDL particles by its apo E content
Macrophag presence is decreased in the vessel wall as a result of HDL-effect
HDL has anti-oxidant activity

20
Q

Cardiovascular protective functions of HDL particle, EXCEPT:
Enhances the peripheral uptake of LDL particles by its apo E content
Enhances the receptor mediated endocytosis of CHY- and VLDL-remnant particles by its apo C and apo E content
Macrophag presence is enhanced in the vessel wall by the anti-apoptotic effect of HDL
HDL enhances the PGI2 production of endothelial cell thereby inhibiting platelet adhesion

A

Macrophag presence is enhanced in the vessel wall by the anti-apoptotic effect of HDL

21
Q

Processes important in the formation of pro-inflammatoric HDL particle:
Apo A-1 modifying effect of myloperoxidase
Glycation occuring in diabetes mellitus
Chronic inflammatory processes
Hypertension

A

Apo A-1 modifying effect of myloperoxidase

22
Q 
Possible clinical symptom(s) of familiar hyperchylomicronaemia:
hepatosplenomegaly
lipidaemia retinalis
acute pancreatitis
xanthoma tendinosum
A

hepatosplenomegaly
lipidaemia retinalis
acute pancreatitis

23
Q 
Possible clinical symptom(s) of familiar dysbetahyperlipidaemia
yellowish xanthomas in palm rinkles
tuberoeruptive xanthomas
tuberous xanthomas
xanthoma tendinosum
A

yellowish xanthomas in palm rinkles
tuberoeruptive xanthomas
tuberous xanthomas

24
Q 
Possible clinical symptom(s) of familiar hypercholesterinaemia:
arcus corneae
xanthoma tendinosum
tuberous xanthomas
tuberoeruptive xanthomas
A

arcus corneae
xanthoma tendinosum
tuberous xanthomas

25
Q 
Potential caus(es) of familiar hypercholesterinaemia:
LDL receptor mutation
Apo E mutation
Gain of function mutation of PCSK9
Apo B-48 deficiency
A

LDL receptor mutation

Gain of function mutation of PCSK9

26
Q 
Potential caus(es) of familiar hypercholesterinaemia:
Apo B mutation
Loss of function mutation of PCSK9
LDL receptor mutation
Apo B-48 deficiency
A

Apo B mutation

LDL receptor mutation

27
Q 
Potential caus(es) of familiar dysbetalipoproteinaemia:
Apo B mutation
Apo E4 mutation
Apo A mutation
Homozygous apo E2 mutation
A

Homozygous apo E2 mutation

28
Q 
Which disease is associated with elevated serum triglyceride (TG) level
Cushing syndrome
Diabetes mellitus
von Gierke disease
Chronic renal failure
A

von Gierke disease

Pathophysiology 1 MCQ (16 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions