7. Cdk/cyclin complexes Flashcards
1
Q
Which points is the cell cycle controlled at?
A
G2/M
M/A
Restriction point
G1/S
2
Q
How are Cdks inactive in absence of cyclin subunit?
A
The T loop of the Cdk occludes the catalytic active site
3
Q
What does p16INK do?
A
Blocks Cyclin D association to Cdk4
4
Q
What does p27 do?
A
Blocks ATP binding by Cyclin A/Cdk2 complex
5
Q
What does p21 do?
A
Blocks substrate binding by both Cdk1/Cyclin and Cdk2/Cyclin complexes
6
Q
Mitotic cyclin-Cdks
A
Cyclin A-Cdk1
Cyclin B - Cdk1
7
Q
Mid G1 cyclin-Cdks
A
Cyclin D-Cdk4
Cyclin D- Cdk6
8
Q
Late G1 cyclin-Cdk
A
Cyclin E-Cdk2
9
Q
S phase cyclin-Cdk
A
Cyclin A-Cdk2
10
Q
How is cyclin B/Cdk1 activity inhibited during G2?
A
Phosphorylation of tyrosine 15 in the ATP binding pocket of Cdk1 by Wee1 kinase
