Psychiatric Genetics Flashcards
the phenomenon in which each generation develops a genetic disease at an earlier age is called…
anticipation
psychiatric symptoms of huntingtons?
depression compulsions anxiety suicidality psychosis blunted affect aggression
what is the genetic changed in huntingtons?
CAG repeat
CAG encodes what protein?
polyglutamine
if there are less than __ repeats you will not develop huntingtons
32
if there are more than __ repeats you will develop huntingtons
38
the more repeats the more likely you will develop huntingtons at an earlier age T or F
T
if a mum has 42 repeats and has HD she will pass __ repeats onto her children
42
HD is usually asymptomatic until adulthood T or F
T
what FH of alzheimers indicates a mutation may be present?
3 affected individuals under 60
if 1 affected 1st degree relative is affected with dementia, what is the risk of you developing it?
25%
